Consumption of Ocimum sanctum L. and Citrus paradisi infusions modulates lipid metabolism and insulin resistance in obese rats

• Published in: Food & function Vol. 5; no. 5; pp. 927 - 935
• Main Authors: Gamboa-Gómez, Claudia, Salgado, Luis M, González-Gallardo, Adriana, Ramos-Gómez, Minerva, Loarca-Piña, Guadalupe, Reynoso-Camacho, Rosalía
• Format: Journal Article
• Language: English
• Published: England 01.05.2014
• Subjects: Animals; Citrus paradisi - chemistry; Humans; Insulin Resistance; Lipid Metabolism - drug effects; Lipogenesis - drug effects; Liver - drug effects; Liver - metabolism; Male; Obesity - drug therapy; Obesity - genetics; Obesity - metabolism; Ocimum - chemistry; Plant Extracts - administration & dosage; PPAR alpha - genetics; PPAR alpha - metabolism; Rats; Rats, Sprague-Dawley; Sterol Regulatory Element Binding Protein 1 - genetics; Sterol Regulatory Element Binding Protein 1 - metabolism; Triglycerides - metabolism

A high saturated fat and fructose diet leads to metabolic disorders through dysregulation of genes involved in lipid metabolism. Consumption of plant infusions reduces these obesity alterations, but the precise mechanism remains unclear. In this study, we investigated the effect and the possible mec...