Combining ranibizumab with calcium dobesilate to reduce injection frequency in diabetic macular edema treatment

• Published in: International ophthalmology Vol. 45; no. 1; p. 203
• Main Authors: Chen, Jian-Ying, Pan, Hong-Wei, Zhang, Xiao-Ming, Liu, Jing-Min, Chan, Sum-Yuet, Liu, Ting-Ting, Ma, Jian-yi, Liu, Qi, Yi, Wan-Zhao, Wu, Ya-Ni, Gu, Shuo-Shuo, Xia, Ling-Xiao, Meng, Jing
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 17.05.2025; Springer Nature B.V
• Subjects: Acuity; Aged; Angiogenesis Inhibitors - administration & dosage; Calcium; Calcium Dobesilate - administration & dosage; Combination therapy; Comparative analysis; Diabetes mellitus; Diabetic Retinopathy - complications; Diabetic Retinopathy - diagnosis; Diabetic Retinopathy - drug therapy; Drug Therapy, Combination; Edema; Effectiveness; Female; Follow-Up Studies; Humans; Injection; Intravitreal Injections; Macula Lutea - pathology; Macular Edema - diagnosis; Macular Edema - drug therapy; Macular Edema - etiology; Male; Medicine; Medicine & Public Health; Middle Aged; Ophthalmology; Original Paper; Patients; Ranibizumab - administration & dosage; Therapy; Tomography, Optical Coherence - methods; Treatment Outcome; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Visual Acuity; Visual observation; Calcium dobesilate; Efficacy; Intravitreal injections; Diabetic macular edema; Ranibizumab

Background This study explores the potential of calcium dobesilate combined with intravitreal ranibizumab injections to reduce the treatment frequency in patients with DME-induced visual impairment and observes the clinical outcomes. Methods In this investigation involving 90 DME patients, a compara...