Rpv2 is part of a cluster of NLRs specific to Vitis rotundifolia and confers total resistance to grapevine downy mildew

Key message The Rpv2 locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V. rotundifolia. Downy mildew caused by the oomycete Plasmopara viticola is one of the most important diseases affecting grapevine. Resistant varie...

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Published inTheoretical and applied genetics Vol. 138; no. 8; p. 177
Main Authors Marsan, Laurie, Prado, Emilce, Wiedemann-Merdinoglu, Sabine, Schmidlin, Laure, Blanc, Sophie, Delame, Marion, Schnee, Sylvain, Arti, Burak, Barnabé, Guillaume, Velt, Amandine, Dumas, Vincent, Merdinoglu, Didier, Rustenholz, Camille, Mestre, Pere
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 08.07.2025
Springer Nature B.V
Subjects
Agriculture
Biochemistry
Biomedical and Life Sciences
Biotechnology
Breeding
Chromosome Mapping
Chromosomes
Disease Resistance - genetics
Downy mildew
Environmental impact
Females
Gene mapping
Genes
Genes, Plant
Genetic Markers
Genomics
Genotype
Genotype & phenotype
Leaves
Life Sciences
Multigene Family
NLR Proteins - genetics
Oomycetes
Original Article
Pathogens
Peronospora
Phenotype
Plant Biochemistry
Plant Breeding/Biotechnology
Plant Diseases - genetics
Plant Diseases - microbiology
Plant Genetics and Genomics
Plant Proteins - genetics
Proteins
Recombinants
Vitis - genetics
Vitis - microbiology
Vitis rotundifolia
Wines
France
Online AccessGet full text
ISSN0040-5752
1432-2242
1432-2242
DOI10.1007/s00122-025-04959-z

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Abstract Key message The Rpv2 locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V. rotundifolia. Downy mildew caused by the oomycete Plasmopara viticola is one of the most important diseases affecting grapevine. Resistant varieties are an environmentally friendly tool to control grapevine downy mildew . Efficient breeding for durable resistance requires knowledge of the underlying mechanisms. Here we aimed at identifying the molecular basis of Rpv2 , a gene for total resistance to downy mildew derived from Vitis rotundifolia , and at characterizing its effect on pathogen development. Individuals from two populations segregating for Rpv2 were evaluated for resistance to downy mildew and genotyped. Following genetic mapping, markers flanking Rpv2 were used to screen new populations and identify recombinant individuals. Sequencing of recombinants and in silico chromosome painting was used to reduce the interval containing Rpv2 . Comparative genomics inside the Vitaceae , involving de novo assembly of the V. rotundifolia Regale genome, allowed narrowing down the list of candidate genes. We restrict Rpv2 to a 250 kb genomic region that contains two resistance genes of the NLR type. Comparative genomics analyses could not find orthologs of both NLRs in the other Vitis species studied. We also show that Rpv2 -mediated resistance leads to pathogen arrest early in the infection cycle. Our results show that Rpv2 belongs to the NLR family of resistance genes, contributing thus to understand the potential and risks of its use in breeding programmes and suggesting that combining NLR-type genes may lead to durable resistance
AbstractList The Rpv2 locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V. rotundifolia. Downy mildew caused by the oomycete Plasmopara viticola is one of the most important diseases affecting grapevine. Resistant varieties are an environmentally friendly tool to control grapevine downy mildew. Efficient breeding for durable resistance requires knowledge of the underlying mechanisms. Here we aimed at identifying the molecular basis of Rpv2, a gene for total resistance to downy mildew derived from Vitis rotundifolia, and at characterizing its effect on pathogen development. Individuals from two populations segregating for Rpv2 were evaluated for resistance to downy mildew and genotyped. Following genetic mapping, markers flanking Rpv2 were used to screen new populations and identify recombinant individuals. Sequencing of recombinants and in silico chromosome painting was used to reduce the interval containing Rpv2. Comparative genomics inside the Vitaceae, involving de novo assembly of the V. rotundifolia Regale genome, allowed narrowing down the list of candidate genes. We restrict Rpv2 to a 250 kb genomic region that contains two resistance genes of the NLR type. Comparative genomics analyses could not find orthologs of both NLRs in the other Vitis species studied. We also show that Rpv2-mediated resistance leads to pathogen arrest early in the infection cycle. Our results show that Rpv2 belongs to the NLR family of resistance genes, contributing thus to understand the potential and risks of its use in breeding programmes and suggesting that combining NLR-type genes may lead to durable resistance.KEY MESSAGEThe Rpv2 locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V. rotundifolia. Downy mildew caused by the oomycete Plasmopara viticola is one of the most important diseases affecting grapevine. Resistant varieties are an environmentally friendly tool to control grapevine downy mildew. Efficient breeding for durable resistance requires knowledge of the underlying mechanisms. Here we aimed at identifying the molecular basis of Rpv2, a gene for total resistance to downy mildew derived from Vitis rotundifolia, and at characterizing its effect on pathogen development. Individuals from two populations segregating for Rpv2 were evaluated for resistance to downy mildew and genotyped. Following genetic mapping, markers flanking Rpv2 were used to screen new populations and identify recombinant individuals. Sequencing of recombinants and in silico chromosome painting was used to reduce the interval containing Rpv2. Comparative genomics inside the Vitaceae, involving de novo assembly of the V. rotundifolia Regale genome, allowed narrowing down the list of candidate genes. We restrict Rpv2 to a 250 kb genomic region that contains two resistance genes of the NLR type. Comparative genomics analyses could not find orthologs of both NLRs in the other Vitis species studied. We also show that Rpv2-mediated resistance leads to pathogen arrest early in the infection cycle. Our results show that Rpv2 belongs to the NLR family of resistance genes, contributing thus to understand the potential and risks of its use in breeding programmes and suggesting that combining NLR-type genes may lead to durable resistance.
Key messageThe Rpv2locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V. rotundifolia.Downy mildew caused by the oomycete Plasmopara viticola is one of the most important diseases affecting grapevine. Resistant varieties are an environmentally friendly tool to control grapevine downy mildew. Efficient breeding for durable resistance requires knowledge of the underlying mechanisms. Here we aimed at identifying the molecular basis of Rpv2, a gene for total resistance to downy mildew derived from Vitis rotundifolia, and at characterizing its effect on pathogen development. Individuals from two populations segregating for Rpv2 were evaluated for resistance to downy mildew and genotyped. Following genetic mapping, markers flanking Rpv2 were used to screen new populations and identify recombinant individuals. Sequencing of recombinants and in silico chromosome painting was used to reduce the interval containing Rpv2. Comparative genomics inside the Vitaceae, involving de novo assembly of the V. rotundifolia Regale genome, allowed narrowing down the list of candidate genes. We restrict Rpv2 to a 250 kb genomic region that contains two resistance genes of the NLR type. Comparative genomics analyses could not find orthologs of both NLRs in the other Vitis species studied. We also show that Rpv2-mediated resistance leads to pathogen arrest early in the infection cycle. Our results show that Rpv2 belongs to the NLR family of resistance genes, contributing thus to understand the potential and risks of its use in breeding programmes and suggesting that combining NLR-type genes may lead to durable resistance
The Rpv2 locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V. rotundifolia. Downy mildew caused by the oomycete Plasmopara viticola is one of the most important diseases affecting grapevine. Resistant varieties are an environmentally friendly tool to control grapevine downy mildew. Efficient breeding for durable resistance requires knowledge of the underlying mechanisms. Here we aimed at identifying the molecular basis of Rpv2, a gene for total resistance to downy mildew derived from Vitis rotundifolia, and at characterizing its effect on pathogen development. Individuals from two populations segregating for Rpv2 were evaluated for resistance to downy mildew and genotyped. Following genetic mapping, markers flanking Rpv2 were used to screen new populations and identify recombinant individuals. Sequencing of recombinants and in silico chromosome painting was used to reduce the interval containing Rpv2. Comparative genomics inside the Vitaceae, involving de novo assembly of the V. rotundifolia Regale genome, allowed narrowing down the list of candidate genes. We restrict Rpv2 to a 250 kb genomic region that contains two resistance genes of the NLR type. Comparative genomics analyses could not find orthologs of both NLRs in the other Vitis species studied. We also show that Rpv2-mediated resistance leads to pathogen arrest early in the infection cycle. Our results show that Rpv2 belongs to the NLR family of resistance genes, contributing thus to understand the potential and risks of its use in breeding programmes and suggesting that combining NLR-type genes may lead to durable resistance.
Key message The Rpv2 locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V. rotundifolia. Downy mildew caused by the oomycete Plasmopara viticola is one of the most important diseases affecting grapevine. Resistant varieties are an environmentally friendly tool to control grapevine downy mildew . Efficient breeding for durable resistance requires knowledge of the underlying mechanisms. Here we aimed at identifying the molecular basis of Rpv2 , a gene for total resistance to downy mildew derived from Vitis rotundifolia , and at characterizing its effect on pathogen development. Individuals from two populations segregating for Rpv2 were evaluated for resistance to downy mildew and genotyped. Following genetic mapping, markers flanking Rpv2 were used to screen new populations and identify recombinant individuals. Sequencing of recombinants and in silico chromosome painting was used to reduce the interval containing Rpv2 . Comparative genomics inside the Vitaceae , involving de novo assembly of the V. rotundifolia Regale genome, allowed narrowing down the list of candidate genes. We restrict Rpv2 to a 250 kb genomic region that contains two resistance genes of the NLR type. Comparative genomics analyses could not find orthologs of both NLRs in the other Vitis species studied. We also show that Rpv2 -mediated resistance leads to pathogen arrest early in the infection cycle. Our results show that Rpv2 belongs to the NLR family of resistance genes, contributing thus to understand the potential and risks of its use in breeding programmes and suggesting that combining NLR-type genes may lead to durable resistance
ArticleNumber 177
Author Marsan, Laurie
Blanc, Sophie
Arti, Burak
Merdinoglu, Didier
Delame, Marion
Velt, Amandine
Mestre, Pere
Schmidlin, Laure
Schnee, Sylvain
Wiedemann-Merdinoglu, Sabine
Prado, Emilce
Barnabé, Guillaume
Rustenholz, Camille
Dumas, Vincent
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Snippet Key message The Rpv2 locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V....
The Rpv2 locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V. rotundifolia....
Key messageThe Rpv2locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V....
The Rpv2 locus for total resistance to grapevine downy mildew is mapped to a 250 kb genomic region containing two NLR-type genes specific to V. rotundifolia....
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SubjectTerms Agriculture
Biochemistry
Biomedical and Life Sciences
Biotechnology
Breeding
Chromosome Mapping
Chromosomes
Disease Resistance - genetics
Downy mildew
Environmental impact
Females
Gene mapping
Genes
Genes, Plant
Genetic Markers
Genomics
Genotype
Genotype & phenotype
Leaves
Life Sciences
Multigene Family
NLR Proteins - genetics
Oomycetes
Original Article
Pathogens
Peronospora
Phenotype
Plant Biochemistry
Plant Breeding/Biotechnology
Plant Diseases - genetics
Plant Diseases - microbiology
Plant Genetics and Genomics
Plant Proteins - genetics
Proteins
Recombinants
Vitis - genetics
Vitis - microbiology
Vitis rotundifolia
Wines
Title Rpv2 is part of a cluster of NLRs specific to Vitis rotundifolia and confers total resistance to grapevine downy mildew
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