Cognitive effects of aromatase inhibitors in early breast cancer patients: a prospective study

• Published in: Breast cancer research and treatment Vol. 213; no. 3; pp. 385 - 395
• Main Authors: Giuffrè, Guido Maria, Carbognin, Luisa, Masone Iacobucci, Giovanna, Gistro, Maria, Tanzilli, Antonio, Morganti, Valentina, Fuso, Paola, Raffaele, Mimma, Rossi, Valentina, Paris, Ida, Palazzo, Antonella, Corsi, Domenico Cristiano, Villani, Veronica, Moffa, Federica, Cercato, Maria Cecilia, Perrone, Maria, Massimiani, Gioia, Gerace, Carmen, Giannarelli, Diana, Marra, Camillo, Fabi, Alessandra
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2025; Springer Nature B.V
• Subjects: Adult; Aged; Aromatase; Aromatase Inhibitors - adverse effects; Aromatase Inhibitors - therapeutic use; Breast cancer; Breast Neoplasms - complications; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cancer therapies; Chemotherapy; Chemotherapy, Adjuvant - adverse effects; Clinical trials; Cognition - drug effects; Cognitive ability; Endocrine therapy; Estrogens; Executive function; Female; Humans; Inhibitor drugs; Mastectomy; Medicine; Medicine & Public Health; Memory; Menopause; Middle Aged; Neoplasm Staging; Nervous system; Neuropsychological Tests; Neuropsychology; Oncology; Post-menopause; Premenopause; Prospective Studies; Semantics; Surgery; Toxicity; Womens health; Chemotherapy; Cognitive disorder; Neurological assessment; Early breast cancer; Cognitive function; Aromatase inhibitors
• ISSN: 0167-6806; 1573-7217; 1573-7217
• DOI: 10.1007/s10549-025-07788-2

Purpose Several patients undergoing aromatase inhibitors (AIs) for breast cancer (BC) report cognitive difficulties, although studies on the cognitive effects have yielded mixed findings. This prospective study aimed to investigate the impact on cognitive function of adjuvant AIs and the changes ove...