Epigenetic control of T helper cells differentiation: a mechanistic insight into the association between acute leukemia and coronary artery disease

• Published in: Medical oncology (Northwood, London, England) Vol. 42; no. 7; p. 272
• Main Authors: Roy, Sohini, Shanmugam, Geetha, Pradeep, R., George, Melvin, Sarkar, Koustav
• Format: Journal Article
• Language: English
• Published: New York Springer US 19.06.2025; Springer Nature B.V
• Subjects: Aged; Cardiovascular disease; Cell Differentiation - genetics; Coronary Artery Disease - genetics; Coronary Artery Disease - immunology; Coronary Artery Disease - pathology; Coronary vessels; DNA Methylation; Epigenesis, Genetic; Epigenetics; Female; Hematology; Histones - metabolism; Humans; Internal Medicine; Leukemia; Male; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Paper; Pathology; T-Lymphocytes, Helper-Inducer - immunology; T-Lymphocytes, Helper-Inducer - metabolism; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Vein & artery diseases; Epigenetics; T helper cells; CD4; Acute leukemia (AL); Corona artery disease (CAD); P53; CD4+T helper cells

Even with today’s sophisticated medical procedures, the two top causes of death worldwide continue to be cancer and coronary artery disease (CAD). Compared to patients with other malignancies, people with acute leukemia (AL) have a higher incidence of congestive heart failure. It is yet unknown how...