Prevalence of malignancy and factors affecting outcome of cats undergoing splenectomy

• Published in: Journal of the American Veterinary Medical Association Vol. 261; no. 11; p. 1646
• Main Authors: Rossanese, Matteo, Williams, Heather, Puerta, Benito de la, Scott, Peter, Chanoit, Guillaume, Guillén, Alexandra
• Format: Journal Article
• Language: English
• Published: United States 01.11.2023
• Subjects: Anemia - veterinary; Animals; Cat Diseases - epidemiology; Cats; Dog Diseases - diagnosis; Dogs; Hemangiosarcoma - veterinary; Hemoperitoneum - veterinary; Humans; Prevalence; Retrospective Studies; Splenectomy - adverse effects; Splenectomy - veterinary; Splenic Neoplasms - epidemiology; Splenic Neoplasms - surgery; Splenic Neoplasms - veterinary; feline; mast cell tumor; hemangiosarcoma; splenectomy; hemoabdomen
• DOI: 10.2460/javma.23.05.0258

To determine the prevalence of splenic malignancy in cats undergoing splenectomy and to investigate possible factors associated with post-operative outcome. 62 client-owned cats that underwent splenectomy. Medical records of 4 UK-based referral hospitals were searched and data reviewed retrospectively over 17 years. Factors associated with outcomes post-splenectomy were analyzed. 50 out of 62 cats (81%) were diagnosed with splenic neoplasia. Mast cell tumor ([MCT], 42%), hemangiosarcoma ([HSA], 40%), lymphoma and histiocytic sarcoma (6% each) were the most common tumor types. Fifteen cats (24%) presented with spontaneous hemoabdomen and were all diagnosed with splenic neoplasia. The diagnostic accuracy of cytology to detect splenic malignant lesions was 73% (100% for MCTs and 54% for mesenchymal tumors). Median survival time for cats with nonneoplastic splenic lesions was 715 days (IQR, 18 to 1,368) and 136 days for cats with splenic neoplasia (IQR, 35 to 348); median survival time was longer for cats with splenic MCT when compared to cats with HSA (348 vs 94 days; P < .001). Presence of metastatic disease and anemia (PCV < 24%) at diagnosis were associated with a poorer survival when considering all cats. Presence of anemia, a splenic mass on imaging or spontaneous hemoabdomen were associated with a diagnosis of HSA (P < .001). Benign splenic lesions were uncommon in this cohort of cats. Spontaneous hemoabdomen should prompt the clinician to suspect neoplasia in cats with splenic disease. Anemia and evidence of metastasis at diagnosis were poor prognostic factors regardless of the final diagnosis.