Characterization of 3-Ketosteroid 9α-Hydroxylase, a Rieske Oxygenase in the Cholesterol Degradation Pathway of Mycobacterium tuberculosis

• Published in: The Journal of biological chemistry Vol. 284; no. 15; pp. 9937 - 9946
• Main Authors: Capyk, Jenna K., D’Angelo, Igor, Strynadka, Natalie C., Eltis, Lindsay D.
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 10.04.2009

KshAB (3-Ketosteroid 9α-hydroxylase) is a two-component Rieske oxygenase (RO) in the cholesterol catabolic pathway of Mycobacterium tuberculosis. Although the enzyme has been implicated in pathogenesis, it has largely been characterized by bioinformatics and molecular genetics. Purified KshB, the re...