Periprocedural Bleeding and Thromboembolic Events With Dabigatran Compared With Warfarin: Results From the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) Randomized Trial

• Published in: Circulation (New York, N.Y.) Vol. 126; no. 3; pp. 343 - 348
• Main Authors: HEALEY, Jeff S, EIKELBOOM, John, CONNOLLY, Stuart J, YUSUF, Salim, EZEKOWITZ, Michael, DOUKETIS, James, WALLENTIN, Lars, OLDGREN, Jonas, YANG, Sean, THEMELES, Ellison, HEIDBUCHLE, Hein, AVEZUM, Alvaro, REILLY, Paul
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 17.07.2012
• Subjects: Aged; Aged, 80 and over; anticoagulants; Anticoagulants - administration & dosage; Anticoagulants - adverse effects; atrial fibrillation; Benzimidazoles - administration & dosage; Benzimidazoles - adverse effects; beta-Alanine - administration & dosage; beta-Alanine - adverse effects; beta-Alanine - analogs & derivatives; Biological and medical sciences; Blood and lymphatic vessels; Blood Loss, Surgical - prevention & control; Blood. Blood coagulation. Reticuloendothelial system; Brain Ischemia - prevention & control; Cardiac Pacing, Artificial - adverse effects; Cardiology. Vascular system; Cataract Extraction - adverse effects; Dabigatran; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Female; Follow-Up Studies; Hemorrhage - chemically induced; Hemorrhage - epidemiology; Hemorrhage - prevention & control; Humans; Incidence; Male; Medical sciences; Middle Aged; perioperative; Pharmacology. Drug treatments; Postoperative Complications - epidemiology; Postoperative Complications - prevention & control; Risk Factors; Stroke - prevention & control; stroke prevention; surgery; Thromboembolism - drug therapy; Thromboembolism - epidemiology; Warfarin - administration & dosage; Warfarin - adverse effects; Arrhythmia; Coumarine derivatives; Thrombin; Cardiovascular disease; Anticoagulant; Dabigatran; Antithrombin; Hemorrhage; Vascular disease; Prevention; Antivitamin K; Heart disease; Surgery; Antithrombotic agent; anticoagulants; Thromboembolism; Cerebrovascular disease; Nervous system diseases; Stroke; Warfarin; Serine endopeptidases; Enzyme; Atrial fibrillation; Enzyme inhibitor; Thrombosis; Excitability disorder; Embolism; Cerebral disorder; Peptidases; perioperative; Treatment; Central nervous system disease; Hydrolases; stroke prevention

Dabigatran reduces ischemic stroke in comparison with warfarin; however, given the lack of antidote, there is concern that it might increase bleeding when surgery or invasive procedures are required. The current analysis was undertaken to compare the periprocedural bleeding risk of patients in the R...