Eukaryotic ADCY7 catalyzes the production of c-di-AMP to activate the NLRP3 inflammasome - Liu, Qiannv; Tang, Zhiheng; Qian, Yan; Wang, Chunlei; Kong, Chun; Li, Mengqian; Geng, Xiangyang; Zhang, Yan; Cheng, Xiangyun; Ren, Chao; Wang, Kai; Bai, Lin; et al. (Nature chemical biology, 2025)
Keywords: 631/250/249; 631/250/255; Adenosine monophosphate; Adenosine triphosphate; Adenylate cyclase; Adenylyl Cyclases - deficiency; Adenylyl Cyclases - genetics; Adenylyl Cyclases - metabolism; Agonists; Animals; Binding; Biochemical Engineering; Biochemistry; Bioorganic Chemistry; Catalysis; Cell Biology; Cell culture; Chemical synthesis; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Clonal deletion; Cyclic AMP; Cytotoxicity; Dimers; Dinucleoside Phosphates - metabolism; Enzymatic activity; Gene deletion; Genes; HEK293 Cells; Humans; Inflammasomes; Inflammasomes - metabolism; Leucine; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial DNA; Mortality; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism; Nucleotides; Physiology; Potassium; Proteins; TLR9 protein; Toll-Like Receptor 9 - agonists; Toll-Like Receptor 9 - metabolism; Toll-like receptors