Multifunctional DNA Nanoflower Applied for High Specific Photodynamic Cancer Therapy In Vivo

• Published in: Chembiochem : a European journal of chemical biology Vol. 25; no. 13; pp. e202400229 - n/a
• Main Authors: Zheng, Hao, Feng, Xue‐Nan, Jin, Xiang‐Wan‐Er, Dai, Zhi‐Qi, Lu, Sha, Cui, Yun‐Xi, Kong, De‐Ming
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 02.07.2024
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Biocompatibility; Cancer; Cancer therapies; cancer treatment; Cell Line, Tumor; Cell Survival - drug effects; Chemotherapy; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA nanoflowers; Drug delivery; Health services; Humans; Medical treatment; Mice; Nanomaterials; Nanostructures - chemistry; Neoplasms - drug therapy; Neoplasms - pathology; Photochemotherapy; Photodynamic therapy; Photosensitivity; Photosensitizing Agents - chemical synthesis; Photosensitizing Agents - chemistry; Photosensitizing Agents - pharmacology; Porphyrins; cancer treatment; DNA nanoflowers; Photodynamic therapy

Photodynamic therapy (PDT) is a newly emerged strategy for disease treatment. One challenge of the application of PDT drugs is the side‐effect caused by the non‐specificity of the photosensitive molecules. Most of the photosensitizers may invade not only the pathogenic cells but also the normal cell...