Impact of Cancer Cachexia Progression on OATP1B1 Transport Activity: Quantitative Analysis Using Coproporphyrin-I as an Endogenous Biomarker

• Published in: Clinical pharmacology and therapeutics Vol. 118; no. 1; p. 128
• Main Authors: Sumimoto, Takahiro, Tanaka, Ryota, Suzuki, Yosuke, Negami, Jun, Sueshige, Yoshio, Oda, Ayako, Shiraiwa, Ken, Inagaki, Takashi, Nishikawa, Kazuo, Tatsuta, Ryosuke, Otsu, Satoshi, Ogata, Masao, Ohno, Keiko, Itoh, Hiroki
• Format: Journal Article
• Language: English
• Published: United States 01.07.2025
• Subjects: Adult; Aged; Biological Transport; Biomarkers - blood; Cachexia - blood; Cachexia - etiology; Cachexia - metabolism; Coproporphyrins - blood; Coproporphyrins - metabolism; Disease Progression; Female; Humans; Interleukin-6 - blood; Liver-Specific Organic Anion Transporter 1 - genetics; Liver-Specific Organic Anion Transporter 1 - metabolism; Male; Middle Aged; Neoplasms - blood; Neoplasms - complications; Tumor Necrosis Factor-alpha - blood

Genetic factors, inflammatory cytokines such as interleukin (IL)-6 and tumor necrosis factor-α (TNF-α), and uremic substances such as 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF) have been reported to affect organic anion transporting polypeptide (OATP)1B1 transport activity. However, th...