Photoredox Catalyzed Single C−F Bond Activation of Trifluoromethyl Ketones: A Solvent Controlled Divergent Access of gem‐Difluoromethylene Containing Scaffolds

• Published in: Chemistry : a European journal Vol. 29; no. 12; pp. e202203428 - n/a
• Main Authors: Ghosh, Soumen, Qu, Zheng‐Wang, Roy, Sourav, Grimme, Stefan, Chatterjee, Indranil
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 24.02.2023
• Subjects: Access control; Agrochemicals; Alkenes; Catalysis; Catalysts; Chemistry; cyclic ketals; C−F bond activation; density functional calculations; Divergence; fluorinated solvent; gem-difluoromethylene unit; Ketones; Molecular structure; Photoredox catalysis; Solvents; Stereoselectivity; Tetrahydrofuran; C−F bond activation; density functional calculations; gem-difluoromethylene unit; fluorinated solvent; photoredox catalysis; cyclic ketals

Selective defluorinative functionalization of trifluoromethyl ketones is a long‐standing challenge owing to the exhaustive mode of the process. To meet the demands for the installation of the gem‐difluoromethylene unit for the construction of the molecular architectures of well‐known pharmaceuticals...