Formation, Selective Encapsulation, and Tautomerization Control of Isoindolone Utilizing Guanidinium Sulfonate Frameworks

• Published in: Chemistry : a European journal Vol. 30; no. 33; pp. e202400957 - n/a
• Main Authors: Chaudhry, Mohammad T., Newman, Justin A., Lee, Alfred Y.
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 12.06.2024
• Subjects: Catalysts; Crystallography; Encapsulation; Host-guest; Hydrogen-Bonded Framework; Structure Elucidation; Tautomerization; Host-guest; Hydrogen-Bonded Framework; Tautomerization; Crystallography; Structure Elucidation

Herein we report the use of tetrakis (guanidinium) pyrenetetrasulfonate (G4PYR) and bis (guanidinium) 1,5‐napthalene disulfonate (G2NDS) to catalyze the cyclization of 2‐cyanobenzamide (1) to isoindolone (2). Moreover, we demonstrate the remarkable selectivity of these guanidinium organosulfonate ho...