Therapeutic Potential of Propolis Extract in Managing Hyperinflammation and Long COVID‐19: A Bioinformatics Study

• Published in: Chemistry & biodiversity Vol. 22; no. 4; pp. e202401947 - n/a
• Main Authors: Anshori, Isa, Marcius, Donny, Syaifie, Putri Hawa, Siregar, Khalish Arsy Al Khairy, Syakuran, Luqman Abdan, Jauhar, Muhammad Miftah, Arda, Adzani Gaisani, Shalannanda, Wervyan, Mardliyati, Etik
• Format: Journal Article
• Language: English
• Published: Switzerland Wiley Subscription Services, Inc 01.04.2025
• Subjects: Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Bioinformatics; Computational Biology; COVID-19; COVID-19 Drug Treatment; Epstein-Barr virus; Flavonoids; Flavonoids - chemistry; Flavonoids - pharmacology; Herbal medicine; Humans; Inflammation; Inflammation - drug therapy; LC–MS/MS; Long COVID; Molecular docking; Molecular Docking Simulation; molecular dynamic; network pharmacology; Pharmacology; Propolis; Propolis - chemistry; Propolis - pharmacology; Propolis - therapeutic use; SARS-CoV-2 - drug effects; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Stat1 protein; Viral diseases; molecular docking; COVID‐19; inflammation; network pharmacology; propolis; molecular dynamic; LC–MS/MS

ABSTRACT Hyperinflammation is a significant factor in long COVID, impacting over 65 million post‐COVID‐19 individuals globally. Herbal remedies, including propolis, show promise in reducing severity and pro‐inflammatory cytokines. However, the natural pharmacological role of propolis in COVID‐19 man...