Supplemental hydrogen sulphide protects transplant kidney function and prolongs recipient survival after prolonged cold ischaemia–reperfusion injury by mitigating renal graft apoptosis and inflammation

• Published in: BJU international Vol. 110; no. 11c; pp. E1187 - E1195
• Main Authors: Lobb, Ian, Mok, Amy, Lan, Zhu, Liu, Weihua, Garcia, Bertha, Sener, Alp
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.2012; Wiley Subscription Services, Inc
• Subjects: Animals; Apoptosis - drug effects; Dietary Supplements; Disease Models, Animal; graft function; Graft Survival - drug effects; Hydrogen Sulfide - administration & dosage; hydrogen sulphide; Inflammation - pathology; Inflammation - prevention & control; ischaemia–reperfusion injury; Kidney - drug effects; Kidney - pathology; Kidney - surgery; Kidney Transplantation; Male; organ preservation; Organ Preservation - methods; Rats; Rats, Inbred Lew; renal transplantation; Reperfusion Injury - pathology; Reperfusion Injury - prevention & control; survival

What's known on the subject? and What does the study add? Hydrogen sulphide (H2S) has recently been classified as a member of the family of small gaseous molecules called gasotransmitters and has been found to have many important physiological functions. Several recent studies have elucidated t...