Injectable Gelled Multiple Emulsion for Glucose-Responsive Insulin Delivery

• Published in: Advanced healthcare materials Vol. 13; no. 26; p. e2304195
• Main Authors: Boakye-Yiadom, Kofi Oti, Chen, Qijing, Teng, Yilong, Zhang, Chenshuang, Hu, Bin, Zhang, Xue-Qing
• Format: Journal Article
• Language: English
• Published: Germany 01.10.2024
• Subjects: Animals; Blood Glucose - drug effects; Blood Glucose - metabolism; Diabetes Mellitus, Experimental - drug therapy; Diabetes Mellitus, Type 1 - drug therapy; Diabetes Mellitus, Type 1 - metabolism; Drug Delivery Systems - methods; Emulsions - chemistry; Gels - chemistry; Glucose - chemistry; Glucose - metabolism; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - chemistry; Hypoglycemic Agents - pharmacology; Insulin - administration & dosage; Insulin - chemistry; Insulin - pharmacology; Male; Mice; injectable gelled multiple emulsions; glucose‐responsive; insulin delivery; PVPBA homopolymer; diabetes

A glucose-responsive insulin delivery system that sustains blood glucose equilibrium for an extended duration can address the low therapeutic window of insulin in diabetes treatment. Herein, insulin is loaded in a water-in-oil-in-water (W /O/W ) gelled multiple emulsion using poly (4-vinylphenylboro...