In Situ Assembled Metal-Phenolic Nanozyme Biointerfaces Revitalize Stem Cells and Optimize Diabetic Implant Osseointegration

• Published in: Advanced healthcare materials Vol. 14; no. 10; p. e2404804
• Main Authors: Chen, Xinxiao, Wang, Weijia, Hu, Yuhan, Sun, Jiao, Zhang, Liguo, Chen, Yi, Liu, Jin, Yu, Yang, Li, Jianhua, Ge, Shaohua
• Format: Journal Article
• Language: English
• Published: Germany 01.04.2025
• Subjects: Animals; Catechin - analogs & derivatives; Catechin - chemistry; Catechin - pharmacology; Cell Adhesion - drug effects; Cell Differentiation - drug effects; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacology; Copper - chemistry; Copper - pharmacology; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - pathology; Male; Mesenchymal Stem Cells - metabolism; Nanostructures - chemistry; Osseointegration - drug effects; Osteogenesis - drug effects; Prostheses and Implants; Rats; Rats, Sprague-Dawley; ligand−metal charge transfer; nanozyme; ROS scavenging; diabetes; implants; osseointegration

The hyperglycemic microenvironment of diabetes inevitably leads to the accumulated reactive oxygen species (ROS) and impairs the function of stem cells, thereby impeding the process of osseointegration after implant placement. In this study, a self-assembled metal-phenolic nanozyme coating is presen...