Dearomatizing Photocyclization and Oxidative Aromatization: Constructing Polycyclic Arenes from Styrenes
The direct construction of polycyclic arenes through ring formation using simple building blocks is highly appealing but remains challenging in organic chemistry. In this study, we introduce an efficient cascade reaction that combines dearomatizing photocyclization with oxidative aromatization, driv...
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| Published in | Chemistry, an Asian journal Vol. 20; no. 10; p. e202401671 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Germany
15.05.2025
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| Subjects | |
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| Abstract | The direct construction of polycyclic arenes through ring formation using simple building blocks is highly appealing but remains challenging in organic chemistry. In this study, we introduce an efficient cascade reaction that combines dearomatizing photocyclization with oxidative aromatization, driven by organophotocatalysis. Conducted under mild, transition-metal-free conditions, this reaction seamlessly converts styrene derivatives into a diverse array of functionalized polycyclic aromatic compounds with good yields and regioselectivity. This approach provides a straightforward and economical route to valuable polycyclic arenes, starting from readily available and abundant styrene derivatives. |
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| AbstractList | The direct construction of polycyclic arenes through ring formation using simple building blocks is highly appealing but remains challenging in organic chemistry. In this study, we introduce an efficient cascade reaction that combines dearomatizing photocyclization with oxidative aromatization, driven by organophotocatalysis. Conducted under mild, transition-metal-free conditions, this reaction seamlessly converts styrene derivatives into a diverse array of functionalized polycyclic aromatic compounds with good yields and regioselectivity. This approach provides a straightforward and economical route to valuable polycyclic arenes, starting from readily available and abundant styrene derivatives. |
| Author | Zhao, Qianyi Lin, Yu-Mei Gong, Lei Huang, Tao He, Yuhang Li, Dong |
| Author_xml | – sequence: 1 givenname: Dong surname: Li fullname: Li, Dong organization: Key Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China – sequence: 2 givenname: Tao surname: Huang fullname: Huang, Tao organization: Key Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China – sequence: 3 givenname: Yuhang surname: He fullname: He, Yuhang organization: Key Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China – sequence: 4 givenname: Qianyi surname: Zhao fullname: Zhao, Qianyi organization: School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Hennan, 453007, China – sequence: 5 givenname: Lei orcidid: 0000-0002-4478-6880 surname: Gong fullname: Gong, Lei organization: Key Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China – sequence: 6 givenname: Yu-Mei orcidid: 0000-0002-7287-9873 surname: Lin fullname: Lin, Yu-Mei organization: Key Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39831542$$D View this record in MEDLINE/PubMed |
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| Keywords | [4+2] annulation aromatization styrenes photocyclization |
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| Title | Dearomatizing Photocyclization and Oxidative Aromatization: Constructing Polycyclic Arenes from Styrenes |
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