Pharmacological inhibition to examine the role of DGAT1 in dietary lipid absorption in rodents and humans

• Published in: American journal of physiology: Gastrointestinal and liver physiology Vol. 304; no. 11; pp. G958 - G969
• Main Authors: Maciejewski, Benjamin S., LaPerle, Jennifer L., Chen, Danny, Ghosh, Avijit, Zavadoski, William J., McDonald, Thomas S., Manion, Tara B., Mather, Dawn, Patterson, Terrell A., Hanna, Maya, Watkins, Steven, Gibbs, E. Michael, Calle, Roberto A., Steppan, Claire M.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.06.2013
• Subjects: Adolescent; Adult; Animals; Case-Control Studies; Diacylglycerol O-Acyltransferase - antagonists & inhibitors; Diacylglycerol O-Acyltransferase - genetics; Diacylglycerol O-Acyltransferase - metabolism; Dietary Fats - blood; Dietary Fats - metabolism; Dose-Response Relationship, Drug; Enterocytes - metabolism; Enzyme Inhibitors - pharmacokinetics; Enzyme Inhibitors - pharmacology; Fatty acids; Fatty Acids, Unsaturated - blood; Fatty Acids, Unsaturated - metabolism; Female; Humans; Intestinal Absorption - drug effects; Intestinal Mucosa - metabolism; Lipid Metabolism - drug effects; Lipids; Male; Metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Oxazepines - pharmacokinetics; Oxazepines - pharmacology; Pathogenesis; Postprandial Period; Rats; Rats, Sprague-Dawley; Rodents; Triglycerides - blood; Triglycerides - metabolism; Vitamin A; Vitamin A - metabolism; lipid absorption; vitamin A; triglycerides; DGAT1; lipid metabolism

Alterations in fat metabolism, in particular elevated plasma concentrations of free fatty acids and triglycerides (TG), have been implicated in the pathogenesis of Type 2 diabetes, obesity, and cardiovascular disease. Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a member of the large family of...