An efficient route from trifluoroacetates to water soluble free amines using Diaion HP-20

• Published in: Amino acids Vol. 30; no. 1; pp. 95 - 98
• Main Authors: Korda, A, Wróbel, Z, Gwardiak, K
• Format: Journal Article
• Language: English
• Published: Austria Springer Nature B.V 01.02.2006
• Subjects: Adsorption; Amines - chemical synthesis; Amines - chemistry; Ion Exchange Resins; Lysine - analogs & derivatives; Lysine - chemical synthesis; Lysine - chemistry; Magnetic Resonance Spectroscopy; Molecular Structure; Oligopeptides - chemical synthesis; Oligopeptides - chemistry; Ornithine - analogs & derivatives; Ornithine - chemical synthesis; Ornithine - chemistry; Polystyrenes; Solubility; Trifluoroacetic Acid - chemistry; Water

A series of polybasic lysine and ornithine derivatives were synthesised as trifluoroacetate salts. Attempts to prepare their free amines according to standard methodology were not successful due to the excellent water solubility of these compounds. Free amines were however efficiently obtained if th...