Recent developments in dynamic kinetic resolution

• Published in: Tetrahedron Vol. 67; no. 21; pp. 3769 - 3802
• Main Author: Pellissier, Hélène
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 27.05.2011; Elsevier
• Subjects: Bioconversions. Hemisynthesis; Biological and medical sciences; Biotechnology; Catalysis; Catalysts: preparations and properties; Chemistry; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; General and physical chemistry; Kinetics and mechanisms; Methods. Procedures. Technologies; Organic chemistry; Reactivity and mechanisms; Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry; de; DMSO; py; Cp; TFA; dmpe; Pa; BINAP; PYBOX; TFE; Tf; DPEN; Cy; DBU; Ph; Thio; SDP; Ts; BIPHEP; ee; dba; Pr; TBS; TBDPS; DKR; Non; BARF; Naph; Tol; TBAI; GABA; Me; SEM; DACH; Pent; BINOL; DIFLUORPHOS; NADPH; DIEA; Ac; Hept; DMAPEN; PHOX; Ms; LDA; L; DABCO; Et; Ar; THF; Troc; Cod; CPME; DMF; c; PMB; DMM; BTAH; Nu; AIBN; MOM; Bn; DYKAT; Fu; TEA; Bu; HEPES; Bz; Hex; Atm; TMS; Enzymatic method; Chiral auxiliary; Asymmetric synthesis; Optical resolution; Kinetics; Kinetic resolution; Catalyst

This review is intended to update the principal techniques used to obtain DKR by either enzymatic or non-enzymatic methods and illustrates the diversity of useful products that can be obtained through this powerful concept, covering the literature from 2008 to 2010. The resolution of stereoisomers h...