Caveolin-1 Controls Airway Epithelial Barrier Function. Implications for Asthma

• Published in: American journal of respiratory cell and molecular biology Vol. 49; no. 4; pp. 662 - 671
• Main Authors: Hackett, Tillie-Louise, de Bruin, Harold G., Shaheen, Furquan, van den Berge, Maarten, van Oosterhout, Antoon J., Postma, Dirkje S., Heijink, Irene H.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.10.2013
• Subjects: Adherens Junctions - genetics; Adherens Junctions - immunology; Adherens Junctions - metabolism; Adolescent; Adult; Animals; Asthma - genetics; Asthma - immunology; Asthma - metabolism; beta Catenin - genetics; beta Catenin - immunology; beta Catenin - metabolism; Bronchi - immunology; Bronchi - metabolism; Cadherins - genetics; Cadherins - immunology; Cadherins - metabolism; Caveolin 1 - genetics; Caveolin 1 - immunology; Caveolin 1 - metabolism; Cell Adhesion - genetics; Cell Adhesion - immunology; Cell Adhesion Molecules - genetics; Cell Adhesion Molecules - immunology; Cell Adhesion Molecules - metabolism; Child; Down-Regulation; Epidermal Growth Factor - genetics; Epidermal Growth Factor - immunology; Epidermal Growth Factor - metabolism; Epithelial Cells - immunology; Epithelial Cells - metabolism; Female; Humans; Male; Pyroglyphidae - immunology; Respiratory Mucosa - immunology; Respiratory Mucosa - metabolism; Th2 Cells - immunology; Th2 Cells - metabolism; Up-Regulation

The molecular basis for airway epithelial fragility in asthma has remained unclear. We investigated whether the loss of caveolin-1, the major component of caveolae and a known stabilizer of adherens junctions, contributes to epithelial barrier dysfunction in asthma. We studied the expression of cave...