Photoelectrochemical biosensors: New insights into promising photoelectrodes and signal amplification strategies

[Display omitted] •Explores the scope of photocatalytic nanomaterials in PEC bioanalysis.•Plasmonic nanoparticle and carbon materials boost the PEC sensitivity.•Recent strategies on signal amplification in catalytic and affinity based PEC biosensors are summarised.•Underlying mechanism of interactio...

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Published inJournal of photochemistry and photobiology. C, Photochemistry reviews Vol. 24; pp. 43 - 63
Main Authors Devadoss, Anitha, Sudhagar, Pitchaimuthu, Terashima, Chiaki, Nakata, Kazuya, Fujishima, Akira
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.09.2015
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Abstract [Display omitted] •Explores the scope of photocatalytic nanomaterials in PEC bioanalysis.•Plasmonic nanoparticle and carbon materials boost the PEC sensitivity.•Recent strategies on signal amplification in catalytic and affinity based PEC biosensors are summarised.•Underlying mechanism of interaction between biomolecules and photoexcited charge carriers from semiconductor surfaces is illustrated.•The implication of dual sensitizers is futuristic in PEC biosensing. The photoelectrochemical (PEC) process is a promising low-cost approach to convert chemical energy to electricity under light illumination and applied potential. PEC biosensing has attracted huge attention because of its ability to detect biomolecules through the photocurrent generated from biomolecule oxidation. However, important factors in the mechanism of PEC biosensing, particularly photoexcited (charge) carrier generation and separation at nano-bio interfaces, are not well explored. Therefore, with the objective of emphasising the implications of photoexcited (charge) carrier transport, here we review recent efforts indicating the significance of electrode design to enhance the performance of PEC biosensor with semiconductor photocatalytic materials. Besides enzymatic PEC biosensors, the underlying beneficial mechanism of direct oxidisation of biomolecules onto a wide range of semiconductor photocatalyst surfaces by the photogenerated holes is briefly discussed. This review is primarily divided into three parts: materials, signal amplification, and promising device architectures, based on recent advances in PEC biosensors. In addition, this review outlines the strategies used to detect a wide range of bioanalytes. After a summary of PEC sensing architectures, the review concludes with an outlook and the current challenges in fabricating solar-light-driven and self-powered biosensors using nanostructured photocatalytic semiconductors. The PEC biosensing schemes presented in this review provide unambiguous operating guidelines of this subject to facilitate our understanding of the compatibility between semiconductor photocatalysts and bioanalytes.
AbstractList [Display omitted] •Explores the scope of photocatalytic nanomaterials in PEC bioanalysis.•Plasmonic nanoparticle and carbon materials boost the PEC sensitivity.•Recent strategies on signal amplification in catalytic and affinity based PEC biosensors are summarised.•Underlying mechanism of interaction between biomolecules and photoexcited charge carriers from semiconductor surfaces is illustrated.•The implication of dual sensitizers is futuristic in PEC biosensing. The photoelectrochemical (PEC) process is a promising low-cost approach to convert chemical energy to electricity under light illumination and applied potential. PEC biosensing has attracted huge attention because of its ability to detect biomolecules through the photocurrent generated from biomolecule oxidation. However, important factors in the mechanism of PEC biosensing, particularly photoexcited (charge) carrier generation and separation at nano-bio interfaces, are not well explored. Therefore, with the objective of emphasising the implications of photoexcited (charge) carrier transport, here we review recent efforts indicating the significance of electrode design to enhance the performance of PEC biosensor with semiconductor photocatalytic materials. Besides enzymatic PEC biosensors, the underlying beneficial mechanism of direct oxidisation of biomolecules onto a wide range of semiconductor photocatalyst surfaces by the photogenerated holes is briefly discussed. This review is primarily divided into three parts: materials, signal amplification, and promising device architectures, based on recent advances in PEC biosensors. In addition, this review outlines the strategies used to detect a wide range of bioanalytes. After a summary of PEC sensing architectures, the review concludes with an outlook and the current challenges in fabricating solar-light-driven and self-powered biosensors using nanostructured photocatalytic semiconductors. The PEC biosensing schemes presented in this review provide unambiguous operating guidelines of this subject to facilitate our understanding of the compatibility between semiconductor photocatalysts and bioanalytes.
Author Devadoss, Anitha
Fujishima, Akira
Terashima, Chiaki
Sudhagar, Pitchaimuthu
Nakata, Kazuya
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IngestDate Tue Jul 01 01:22:53 EDT 2025
Thu Apr 24 23:07:15 EDT 2025
Fri Feb 23 02:31:01 EST 2024
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Keywords Photoelectrodes
Biomolecules
Photoelectrochemical biosensors
Signal amplification
Language English
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elsevier_sciencedirect_doi_10_1016_j_jphotochemrev_2015_06_002
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2015-09-00
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  text: September 2015
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PublicationTitle Journal of photochemistry and photobiology. C, Photochemistry reviews
PublicationYear 2015
Publisher Elsevier B.V
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Snippet [Display omitted] •Explores the scope of photocatalytic nanomaterials in PEC bioanalysis.•Plasmonic nanoparticle and carbon materials boost the PEC...
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SubjectTerms Biomolecules
Photoelectrochemical biosensors
Photoelectrodes
Signal amplification
Title Photoelectrochemical biosensors: New insights into promising photoelectrodes and signal amplification strategies
URI https://dx.doi.org/10.1016/j.jphotochemrev.2015.06.002
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