Extensive microstructural changes in association and commissural fibers in adults with childhood maltreatment: An automated fiber quantification study

• Published in: Journal of affective disorders Vol. 389; p. 119746
• Main Authors: Du, Yanxuan, Huang, Huiyuan, Qiu, Yidan, Chen, Taihan, Liu, Xia, Su, Liujie, Li, Xinrui, Huang, Ruiwang
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.11.2025
• Subjects: Adult; Adult Survivors of Child Abuse - psychology; Automated fiber quantification; Brain - pathology; Child; Child Abuse - psychology; Childhood maltreatment; Diffusion Tensor Imaging; Emotion dysregulation; Female; Humans; Male; Psychiatric/Mental Health; Reward; Reward dependence; Support vector regression; White matter; White Matter - diagnostic imaging; White Matter - pathology; Young Adult; Reward dependence; Emotion dysregulation; Support vector regression; Childhood maltreatment; Automated fiber quantification; White matter

Childhood maltreatment (CM) is a pervasive global issue with heightened risk of both emotion dysregulation and reward dependence related behavioral problems and significantly affects microstructure of brain white matter (WM). Yet the specific alterations of WM microstructure alterations in CM indivi...