An env-like protein encoded by a Drosophila retroelement: evidence that gypsy is an infectious retrovirus
The gypsy element of Drosophila differs from most LTR retrotransposons in containing a third open reading frame that resembles retroviral env genes. The protein encoded by ORF3 is glycosylated and processed, like all retroviral envelope proteins. The protein is expressed at high levels in fly strain...
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| Published in | Genes & development Vol. 8; no. 17; pp. 2046 - 2057 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.09.1994
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The gypsy element of Drosophila differs from most LTR retrotransposons in containing a third open reading frame that resembles retroviral env genes. The protein encoded by ORF3 is glycosylated and processed, like all retroviral envelope proteins. The protein is expressed at high levels in fly strains in which gypsy elements are active. In these strains the protein is found primarily in viral particles. When larvae of fly strains in which gypsy is normally inactive are exposed to sucrose gradient fractions containing these particles, a high level of gypsy insertion activity is observed in their progeny. Thus, gypsy has the expected properties of an insect retrovirus. |
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| AbstractList | The gypsy element of Drosophila differs from most LTR retrotransposons in containing a third open reading frame that resembles retroviral env genes. The protein encoded by ORF3 is glycosylated and processed, like all retroviral envelope proteins. The protein is expressed at high levels in fly strains in which gypsy elements are active. In these strains the protein is found primarily in viral particles. When larvae of fly strains in which gypsy is normally inactive are exposed to sucrose gradient fractions containing these particles, a high level of gypsy insertion activity is observed in their progeny. Thus, gypsy has the expected properties of an insect retrovirus. |
| Author | Song, S U Corces, V G Boeke, J D Kurkulos, M Gerasimova, T |
| Author_xml | – sequence: 1 givenname: S U surname: Song fullname: Song, S U organization: Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218 – sequence: 2 givenname: T surname: Gerasimova fullname: Gerasimova, T – sequence: 3 givenname: M surname: Kurkulos fullname: Kurkulos, M – sequence: 4 givenname: J D surname: Boeke fullname: Boeke, J D – sequence: 5 givenname: V G surname: Corces fullname: Corces, V G |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/7958877$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | AIDS/HIV Animals Antibodies, Monoclonal Base Sequence Crosses, Genetic DNA Primers - genetics DNA, Viral - genetics Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila melanogaster - virology Female Gene Products, env - genetics Gene Products, env - immunology Gene Products, env - metabolism Genes, env Genes, Insect Larva - metabolism Larva - virology Male Microscopy, Immunoelectron Molecular Sequence Data Open Reading Frames Ovary - metabolism Ovary - virology Retroelements Retroviridae - genetics Retroviridae - metabolism Retroviridae - pathogenicity |
| Title | An env-like protein encoded by a Drosophila retroelement: evidence that gypsy is an infectious retrovirus |
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