Novel selective and potent 5-HT reuptake inhibitors with 5-HT1D antagonist activity: chemistry and pharmacological evaluation of a series of thienopyran derivatives - Torrado, Alicia; Lamas, Carlos; Agejas, Javier; Jiménez, Alma; Dı́az, Nuria; Gilmore, Jeremy; Boot, John; Findlay, Jeremy; Hayhurst, Lorna; Wallace, Louise; Broadmore, Richard; Tomlinson, Rosemarie (Bioorganic & medicinal chemistry, 2004)
Keywords: Animals; Biological and medical sciences; Humans; Medical sciences; Neuropharmacology; Neurotransmitters. Neurotransmission. Receptors; Pharmacology. Drug treatments; Pyrans - chemical synthesis; Pyrans - chemistry; Pyrans - pharmacology; Rats; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists - chemical synthesis; Serotonin Antagonists - chemistry; Serotonin Antagonists - pharmacology; Serotonin Uptake Inhibitors - chemical synthesis; Serotonin Uptake Inhibitors - chemistry; Serotonin Uptake Inhibitors - pharmacology; Serotoninergic system; Human; Oxygen sulfur heterocycle; Rat; Serotonin; Rodentia; Selectivity; Reuptake inhibitor; Condensed benzenic compound; In vitro; Naphthalene derivatives; Uptake; 5-HT1D serotonin receptor; Vertebrata; Mammalia; Structure activity relation; Membrane transport; Animal; Bicyclic compound; Affinity; Antagonist; Inhibition; Piperazine derivatives; Chemical synthesis; Carrier protein