Functional T cell deficits after bone marrow transplantation across minor histocompatibility barriers: effects of graft-vs-host disease on precursor frequency of reactive cells

• Published in: The Journal of immunology (1950) Vol. 138; no. 11; pp. 3598 - 3603
• Main Authors: Ferrara, JL, Daley, JP, Burakoff, SJ, Miller, RA
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Assoc Immnol 01.06.1987; American Association of Immunologists
• Subjects: Animals; Antigens, Differentiation, T-Lymphocyte; Antigens, Surface - analysis; Biological and medical sciences; Bone Marrow Transplantation; Cytotoxicity, Immunologic; Flow Cytometry; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Graft vs Host Disease - immunology; Graft vs Host Disease - pathology; Hematopoietic Stem Cells - pathology; Immunity, Cellular; Interleukin-2 - biosynthesis; Mice; Minor Histocompatibility Loci; Spleen - immunology; T-Lymphocytes - immunology; T-Lymphocytes, Cytotoxic - immunology; Tissue, organ and graft immunology; Vertebrata; Mammalia; Mouse; Deficiency; Rodentia; T-Lymphocyte; Bone marrow; Minor histocompatibility locus; Graft versus host reaction; Transplantation

We have studied T cell responses in mice transplanted with bone marrow from H-2-identical, minor histocompatibility loci-nonidentical donors (B10.BR---CBA) in which graft-vs-host disease is induced by the addition of donor T cells. T cell responses to mitogen were examined both in high density, conv...