Asymmetric Synthesis of β-Amino-α-Hydroxy Acids through Lewis Acid-Mediated Addition of Ketene Acetal to Imines
Asymmetric synthesis of β-amino-α-hydroxy acids, key components of medicinally important molecules including Paclitaxel, KRI-1314, amastatin, and microginin, has been attained from the aldimine coupling of chiral imines N-alkylidene-(S)- or (R)-α-methylbenzylamine with (Z)-α-methoxyketene methyltrim...
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Published in | Bulletin of the Chemical Society of Japan Vol. 74; no. 9; pp. 1667 - 1672 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
TOKYO
The Chemical Society of Japan
01.09.2001
Chemical Soc Japan |
Subjects | |
Online Access | Get full text |
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