Oxidized Phosphatidylcholines Trigger TRPA1 and Ryanodine Receptor–dependent Airway Smooth Muscle Contraction

• Published in: American journal of respiratory cell and molecular biology Vol. 69; no. 6; pp. 649 - 665
• Main Authors: Vaghasiya, Jignesh, Dalvand, Azadeh, Sikarwar, Anurag, Mangat, Divleen, Ragheb, Mirna, Kowatsch, Katarina, Pandey, Dheerendra, Hosseini, Seyed Mojtaba, Hackett, Tillie L., Karimi-Abdolrezaee, Soheila, Ravandi, Amir, Pascoe, Christopher D., Halayko, Andrew J.
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.12.2023
• Subjects: Airway management; Allergens - metabolism; Animals; Asthma; Asthma - metabolism; Calcium (extracellular); Calcium (intracellular); Calcium - metabolism; Cells; Cyclic ADP-Ribose - metabolism; Humans; Mice; Muscle contraction; Muscle Contraction - physiology; Myocytes, Smooth Muscle - metabolism; Myosin Light Chains - metabolism; Phosphates; Phosphatidylcholines - metabolism; Respiratory Hypersensitivity - metabolism; Respiratory tract; Ryanodine Receptor Calcium Release Channel - metabolism; Ryanodine receptors; Smooth muscle; TRPA1 Cation Channel - metabolism; airway smooth muscle; OxPC; asthma; airway narrowing; calcium signaling

Asthma pathobiology includes oxidative stress that modifies cell membranes and extracellular phospholipids. Oxidized phosphatidylcholines (OxPCs) in lung lavage from allergen-challenged human participants correlate with airway hyperresponsiveness and induce bronchial narrowing in murine thin-cut lun...