Microtubule—macrotubule transformations induced by volatile anesthetics. Mechanism of macrotubule assembly

Halothane, a widely used volatile anesthetic, transforms crayfish axonal microtubules measuring 240 Å in diameter into enlarged tubular structures (macrotubules) averaging 460 Å in diameter. Tannic acid and negative staining techniques have been used to compare the substructure of microtubules and m...

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Published inJournal of ultrastructure research Vol. 57; no. 3; pp. 237 - 250
Main Author Hinkley, Robert E.
Format Journal Article
LanguageEnglish
Published United States Elsevier B.V 01.01.1976
Subjects
Animals
Astacoidea
Axons - ultrastructure
Enflurane - pharmacology
Ethers - pharmacology
Halothane - pharmacology
Isoflurane - pharmacology
Methoxyflurane - pharmacology
Microtubules - drug effects
Microtubules - ultrastructure
Staining and Labeling
Trichloroethylene - pharmacology
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Abstract Halothane, a widely used volatile anesthetic, transforms crayfish axonal microtubules measuring 240 Å in diameter into enlarged tubular structures (macrotubules) averaging 460 Å in diameter. Tannic acid and negative staining techniques have been used to compare the substructure of microtubules and macrotubules and to determine the mechanism of macrotubule assembly. The tubular transformation is initiated by the dissociation of microtubules into component protofilaments which reassemble into unique “twisted ribbon” intermediate structures. Twisted ribbons appear to form macrotubules when adjacent ribbon gyres come into register and join. Macrotubule formation is rapid and at least partially reversible. Methoxyflurane, isoflurane, enflurane, and trichloroethylene also produce macrotubules by a series of structural modifications identical to those described for halothane. Fluroxene and ether dissociate microtubules but do not lead to macrotubule formation. These data provide new information concerning the effects of volatile anesthetics on microtubular structure and the structural polymorphism of microtubule protein.
AbstractList Halothane, a widely used volatile anesthetic, transforms crayfish axonal microtubules measuring 240 Å in diameter into enlarged tubular structures (macrotubules) averaging 460 Å in diameter. Tannic acid and negative staining techniques have been used to compare the substructure of microtubules and macrotubules and to determine the mechanism of macrotubule assembly. The tubular transformation is initiated by the dissociation of microtubules into component protofilaments which reassemble into unique “twisted ribbon” intermediate structures. Twisted ribbons appear to form macrotubules when adjacent ribbon gyres come into register and join. Macrotubule formation is rapid and at least partially reversible. Methoxyflurane, isoflurane, enflurane, and trichloroethylene also produce macrotubules by a series of structural modifications identical to those described for halothane. Fluroxene and ether dissociate microtubules but do not lead to macrotubule formation. These data provide new information concerning the effects of volatile anesthetics on microtubular structure and the structural polymorphism of microtubule protein.
Author Hinkley, Robert E.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/63568$$D View this record in MEDLINE/PubMed
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Snippet Halothane, a widely used volatile anesthetic, transforms crayfish axonal microtubules measuring 240 Å in diameter into enlarged tubular structures...
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pubmed
elsevier
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Publisher
StartPage 237
SubjectTerms Animals
Astacoidea
Axons - ultrastructure
Enflurane - pharmacology
Ethers - pharmacology
Halothane - pharmacology
Isoflurane - pharmacology
Methoxyflurane - pharmacology
Microtubules - drug effects
Microtubules - ultrastructure
Staining and Labeling
Trichloroethylene - pharmacology
Title Microtubule—macrotubule transformations induced by volatile anesthetics. Mechanism of macrotubule assembly
URI https://dx.doi.org/10.1016/S0022-5320(76)80113-X
https://www.ncbi.nlm.nih.gov/pubmed/63568
Volume 57
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