Comparative Effectiveness and Harms of Antibiotics for Outpatient Diverticulitis : Two Nationwide Cohort Studies

• Published in: Annals of internal medicine Vol. 174; no. 6; p. 737
• Main Authors: Gaber, Charles E, Kinlaw, Alan C, Edwards, Jessie K, Lund, Jennifer L, Stürmer, Til, Peacock Hinton, Sharon, Pate, Virginia, Bartelt, Luther A, Sandler, Robert S, Peery, Anne F
• Format: Journal Article
• Language: English
• Published: United States 01.06.2021
• Subjects: Adolescent; Adult; Ambulatory Care; Amoxicillin-Potassium Clavulanate Combination - adverse effects; Amoxicillin-Potassium Clavulanate Combination - therapeutic use; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - therapeutic use; Clostridium Infections - diagnosis; Comparative Effectiveness Research; Cost of Illness; Diverticulitis - drug therapy; Diverticulitis - surgery; Female; Fluoroquinolones - adverse effects; Fluoroquinolones - therapeutic use; Hospitalization; Humans; Male; Metronidazole - adverse effects; Metronidazole - therapeutic use; Middle Aged; Retrospective Studies; Risk Factors; Young Adult

Outpatient diverticulitis is commonly treated with either a combination of metronidazole and a fluoroquinolone (metronidazole-with-fluoroquinolone) or amoxicillin-clavulanate alone. The U.S. Food and Drug Administration advised that fluoroquinolones be reserved for conditions with no alternative tre...