Fast estimators for the mean function for functional data with detection limits

• Published in: Stat (International Statistical Institute) Vol. 11; no. 1
• Main Authors: Liu, Haiyan, Houwing‐Duistermaat, Jeanine
• Format: Journal Article
• Language: English
• Published: The Hague Wiley Subscription Services, Inc 2022
• Subjects: Asymptotic methods; Asymptotic properties; Biomarkers; detection limit; Estimators; functional data analysis; informative missing; local log‐likelihood mean estimation

In many studies on disease progression, biomarkers are restricted by detection limits, hence informatively missing. Current approaches either ignore the problem by just filling in the value of the detection limit for the missing observations or apply a global approach for estimation of the mean func...