Closed-Loop Control of Reactive Crystallization PART II: Polymorphism Control of L-Glutamic Acid by Sonocrystallization and Seeding

• Published in: Chemical engineering & technology Vol. 33; no. 5; pp. 751 - 756
• Main Authors: Hatakka, H., Alatalo, H., Louhi-Kultanen, M., Lassila, I., Hæggström, E.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.05.2010; WILEY‐VCH Verlag
• Subjects: Crystallization; Polymorphism; Seed crystals; Ultrasound

The impact of different nucleation methods with controlled supersaturation on the polymorphism of L‐glutamic acid crystals was studied in a 50 dm3 semi‐batch crystallizer, in which 1.5 M H2SO4 was fed into a 1.5 M monosodium glutamate solution. Supersaturation was controlled by a feedback loop based...