Oxidation products of stigmasterol interfere with the action of the female sex hormone 17β-estradiol in cultured human breast and endometrium cell lines

• Published in: Molecular nutrition & food research Vol. 51; no. 7; pp. 888 - 898
• Main Authors: Newill, Heike, Loske, Renate, Wagner, Jörg, Johannes, Christian, Lorenz, Reinhard L., Lehmann, Leane
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.07.2007; WILEY‐VCH Verlag
• Subjects: Estrogen-active compounds; Ishikawa cells; MCF-7 cells; Oxyphytosterols; Stigmasterol

Phytosterols are constituents of plant membranes and are thus contained in low concentrations in vegetable products as well as at high concentrations in functional food designed to reduce serum cholesterol levels. Similar to ChOL, phytosterols are oxidized chemically in food and by biotransformation...