Circulating levels of IGF-1 directly regulate bone growth and density

• Published in: The Journal of clinical investigation Vol. 110; no. 6; pp. 771 - 781
• Main Authors: Yakar, Shoshana, Rosen, Clifford J, Beamer, Wesley G, Ackert-Bicknell, Cheryl L, Wu, Yiping, Liu, Jun-Li, Ooi, Guck T, Setser, Jennifer, Frystyk, Jan, Boisclair, Yves R, LeRoith, Derek
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Investigation 01.09.2002
• Subjects: Acids; Animals; Biomedical research; Bone density; Bone Density - physiology; Bone Development - physiology; Carrier Proteins - genetics; Carrier Proteins - metabolism; Glycoproteins - genetics; Glycoproteins - metabolism; Growth Hormone - blood; Growth hormones; Insulin-Like Growth Factor Binding Proteins - blood; Insulin-Like Growth Factor I - genetics; Insulin-Like Growth Factor I - metabolism; Liver; Liver - metabolism; Mice; Mice, Inbred Strains; Mice, Knockout; Proteins; Roles; Tibia - cytology; Tibia - metabolism

IGF-1 is a growth-promoting polypeptide that is essential for normal growth and development. In serum, the majority of the IGFs exist in a 150-kDa complex including the IGF molecule, IGF binding protein 3 (IGFBP-3), and the acid labile subunit (ALS). This complex prolongs the half-life of serum IGFs...