Circulating levels of IGF-1 directly regulate bone growth and density

IGF-1 is a growth-promoting polypeptide that is essential for normal growth and development. In serum, the majority of the IGFs exist in a 150-kDa complex including the IGF molecule, IGF binding protein 3 (IGFBP-3), and the acid labile subunit (ALS). This complex prolongs the half-life of serum IGFs...

Full description

Saved in:
Bibliographic Details
Published inThe Journal of clinical investigation Vol. 110; no. 6; pp. 771 - 781
Main Authors Yakar, Shoshana, Rosen, Clifford J, Beamer, Wesley G, Ackert-Bicknell, Cheryl L, Wu, Yiping, Liu, Jun-Li, Ooi, Guck T, Setser, Jennifer, Frystyk, Jan, Boisclair, Yves R, LeRoith, Derek
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.09.2002
Subjects
Online AccessGet full text

Cover

Loading…