Leishmania infantum β-Tubulin Identified by Reverse Engineering Technology through Phage Display Applied as Theranostic Marker for Human Visceral Leishmaniasis

• Published in: International journal of molecular sciences Vol. 20; no. 8; p. 1812
• Main Authors: Costa, Lourena E., Alves, Patrícia T., Carneiro, Ana Paula, Dias, Ana C. S., Fujimura, Patrícia T., Araujo, Galber R., Tavares, Grasiele S. V., Ramos, Fernanda F., Duarte, Mariana C., Menezes-Souza, Daniel, Briza, Peter, Briza, Fátima F., Coelho, Eduardo A. F., Goulart, Luiz Ricardo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 12.04.2019; MDPI
• Subjects: Antigens; Binding sites; Dogs; Immunoglobulins; Immunology; Infections; Mass spectrometry; Parasites; Parasitic diseases; Peptides; Proteins; Reverse engineering; Scientific imaging; Vaccines; Brazil; diagnosis; Leishmania infantum; vaccine; scFv antibody; β-tubulin protein; phage display
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20081812

Two Leishmania infantum mimotopes (B10 and C01) identified by phage display showed to be antigenic and immunogenic for visceral (VL) and tegumentary (TL) leishmaniasis; however, their biological targets in the parasites have not been identified. The aim of the present study was to investigate the na...