Relative Expression of BATF and CD112 in PBMC of Patients with Chronic Lymphocytic Leukemia

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 24; no. 6; pp. 2171 - 2176
• Main Authors: Najafi, Ahmad, Sabaghi, Matine, Asgarian-Omran, Hossein, Valadan, Reza, Shekarriz, Ramin, Zaboli, Ehsan, Janbabai, Ghasem, Tehrani, Mohsen
• Format: Journal Article
• Language: English
• Published: Thailand West Asia Organization for Cancer Prevention 01.06.2023
• Subjects: Basic-Leucine Zipper Transcription Factors - genetics; Basic-Leucine Zipper Transcription Factors - metabolism; Case-Control Studies; Gene Expression Regulation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell - metabolism; Leukocytes, Mononuclear - metabolism; Nectins - metabolism; Polymerase Chain Reaction; Chronic Lymphocytic Leukemia; T-cell exhaustion; CD112; BATF

BATF, as a transcription factor, and CD112, as a receptor for TIGIT, are involved in T-cell exhaustion. We investigated BATF and CD112 gene expression in the peripheral blood mononuclear cells from CLL patients and healthy subjects. In a case-control study, 33 patients with CLL and 20 sex- and age-m...