Synthesis, Structure Analysis, and Antitumor Activity of (R)-2,4-Dioxo-5-fluoro-1-[1-(methoxycarbonyl) Ethylaminocarbonylmethyl]-1,2,3,4-tetrahydropyrimidine

• Published in: Chinese journal of chemistry Vol. 25; no. 3; pp. 417 - 421
• Main Authors: Yuan, Ji-Xin, Cai, Xiao-Qing, Chen, Di-Mei, Hu, Mao-Lin
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.03.2007; WILEY‐VCH Verlag; Wiley
• Subjects: 5-FUAPM; antitumor activity; Chemistry; Chemistry, Multidisciplinary; Physical Sciences; Science & Technology; structure; synthesis; thermal analysis; synthesis; 5-FUAPM; antitumor activity; CRYSTAL-STRUCTURE; COMPLEXES; 2D COORDINATION POLYMER; CYTOTOXICITY; structure; thermal analysis
• ISSN: 1001-604X; 1614-7065
• DOI: 10.1002/cjoc.200790080

A new dipeptide compound, (R)‐2,4‐dioxo‐5‐fluoro‐1‐[1‐(methoxycarbonyl) ethylaminocarbonylmethyl]‐1,2,3, 4‐tetrahydropyrimidine (5‐FUAPM), has been synthesized and identified by means of elemental analysis, IR, 1H NMR and 13C NMR spectra. The single crystal of compound 5‐FUAPM·DMF was also obtained and characterized by DSC‐TGA techniques. The crystal belongs to orthorhombic space group P2121 21 with the cell parameters: a=0.4740(7) nm, b=1.923(3) nm, c=1.9229 nm, α=β=γ=90°, V=1.753 nm3, Z=4, Dc=1.312 g/cm3, Mr=346.32, F(000) =728 and μ=0.111 mm−1. The final R and wR are 0.1378 and 0.2862, respectively. The result of the biological test showed that the compound 5‐FUAPM has certain antitumor activities.