Treatment of arteriovenous malformations of the brain
The treatment of ruptured and unruptured brain arteriovenous malformations (AVMs) is driven by the need to prevent incident or recurrent intracranial hemorrhages. Improving feasibility of the rapidly developing endovascular, neurosurgical, and radiotherapeutic procedures leads to invasive treatment...
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Published in | Current neurology and neuroscience reports Vol. 7; no. 1; pp. 28 - 34 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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United States
Springer Nature B.V
01.01.2007
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Abstract | The treatment of ruptured and unruptured brain arteriovenous malformations (AVMs) is driven by the need to prevent incident or recurrent intracranial hemorrhages. Improving feasibility of the rapidly developing endovascular, neurosurgical, and radiotherapeutic procedures leads to invasive treatment of an increasing number of neurologically intact patients with accidentally diagnosed AVMs. Recent data confirm that the natural history risk of unruptured AVMs is significantly lower than the risk of those presenting with rupture, and the treatment risk of invasive management of unruptured AVMs seems higher than their natural history risk. The treatment decision algorithm for these patients remains unsettled, as no randomized clinical trial data exist on the benefit of invasive AVM treatment for patients with bled or with unbled AVMs. The recently launched study A Randomized Trial of Unruptured Brain AVMs (ARUBA) will be the first trial randomizing patients with nonhemorrhaged AVMs to invasive versus conservative management. |
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AbstractList | The treatment of ruptured and unruptured brain arteriovenous malformations (AVMs) is driven by the need to prevent incident or recurrent intracranial hemorrhages. Improving feasibility of the rapidly developing endovascular, neurosurgical, and radiotherapeutic procedures leads to invasive treatment of an increasing number of neurologically intact patients with accidentally diagnosed AVMs. Recent data confirm that the natural history risk of unruptured AVMs is significantly lower than the risk of those presenting with rupture, and the treatment risk of invasive management of unruptured AVMs seems higher than their natural history risk. The treatment decision algorithm for these patients remains unsettled, as no randomized clinical trial data exist on the benefit of invasive AVM treatment for patients with bled or with unbled AVMs. The recently launched study A Randomized Trial of Unruptured Brain AVMs (ARUBA) will be the first trial randomizing patients with nonhemorrhaged AVMs to invasive versus conservative management. The treatment of ruptured and unruptured brain arteriovenous malformations (AVMs) is driven by the need to prevent incident or recurrent intracranial hemorrhages. Improving feasibility of the rapidly developing endovascular, neurosurgical, and radiotherapeutic procedures leads to invasive treatment of an increasing number of neurologically intact patients with accidentally diagnosed AVMs. Recent data confirm that the natural history risk of unruptured AVMs is significantly lower than the risk of those presenting with rupture, and the treatment risk of invasive management of unruptured AVMs seems higher than their natural history risk. The treatment decision algorithm for these patients remains unsettled, as no randomized clinical trial data exist on the benefit of invasive AVM treatment for patients with bled or with unbled AVMs. The recently launched study A Randomized Trial of Unruptured Brain AVMs (ARUBA) will be the first trial randomizing patients with nonhemorrhaged AVMs to invasive versus conservative management.[PUBLICATION ABSTRACT] |
Author | Mohr, Jay P Mast, Henning Choi, Jae H Stapf, Christian Hartmann, Andreas |
Author_xml | – sequence: 1 givenname: Andreas surname: Hartmann fullname: Hartmann, Andreas email: ahart@zedat.fu-berlin.de organization: Stroke Unit, Department of Neurology, Charité Hochschulmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany. ahart@zedat.fu-berlin.de – sequence: 2 givenname: Henning surname: Mast fullname: Mast, Henning – sequence: 3 givenname: Jae H surname: Choi fullname: Choi, Jae H – sequence: 4 givenname: Christian surname: Stapf fullname: Stapf, Christian – sequence: 5 givenname: Jay P surname: Mohr fullname: Mohr, Jay P |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17217851$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Aneurysm, Ruptured - etiology Aneurysm, Ruptured - therapy Arteriovenous Malformations - therapy Brain Diseases - therapy Cerebral Angiography - methods Cerebral Hemorrhage - complications Cerebral Hemorrhage - etiology Clinical trials Embolization, Therapeutic - methods Humans Intracranial Arteriovenous Malformations Neurosurgical Procedures Risk |
Title | Treatment of arteriovenous malformations of the brain |
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