Induction of Homosubtypic and Heterosubtypic Immunity to Influenza Viruses Using a Conserved Internal and External Proteins

• Published in: Current microbiology Vol. 80; no. 6; p. 212
• Main Authors: Maleki, Mahnoosh, Hosseini, Seyed Masoud, Farahmand, Behrokh, Saleh, Maryam, Shokouhi, Hadiseh, Torabi, Ali, Fotouhi, Fatemeh
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2023; Springer Nature B.V
• Subjects: Adjuvants, Immunologic - pharmacology; Animals; Antibodies; Antibodies, Viral; Antibody response; Biomedical and Life Sciences; Biotechnology; CD4 antigen; Cytokines; Helper cells; Homology; Humans; Immunity; Immunogenicity; Immunological memory; Influenza; Influenza A; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza Vaccines; Influenza, Human; Life Sciences; Lymphocytes; Lymphocytes T; Memory cells; Mice; Mice, Inbred BALB C; Microbiology; Orthomyxoviridae; Proteins; Viruses

The immunogenicity and protective properties of the designed recombinant fusion peptide of 3M2e and truncated nucleoprotein (trNP), originating from Influenza A virus, were investigated in the BALB/c mice model in comparison with the Mix protein (3M2e + trNP). The results were evaluated by antibody...