Impaired macroautophagy confers substantial risk for intellectual disability in children with autism spectrum disorders - Ham, Ahrom; Chang, Audrey Yuen; Li, Hongyu; Bain, Jennifer M.; Goldman, James E.; Sulzer, David; Veenstra-VanderWeele, Jeremy; Tang, Guomei (Molecular psychiatry, 2025)
Keywords: 631/80; 64/60; 692/53/2423; 692/699/476/1373; 82/29; 82/51; 82/80; Adolescent; Animal models; Animals; Autism; Autism Spectrum Disorder - genetics; Autism Spectrum Disorder - metabolism; Autism Spectrum Disorder - physiopathology; Autophagy; Autophagy - genetics; Autophagy - physiology; Autophagy-Related Protein 7 - genetics; Autophagy-Related Protein 7 - metabolism; Behavioral Sciences; Biological Psychology; Biomarkers; Blood cells; Brain; Brain - metabolism; Cell culture; Child; Child, Preschool; Developmental disabilities; Disease Models, Animal; Female; Homeostasis; Humans; Intellectual disabilities; Intellectual Disability - genetics; Intellectual Disability - metabolism; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; Lysosomes; Male; Medicine; Medicine & Public Health; Mice; Neurological diseases; Neurosciences; News; Peripheral blood mononuclear cells; Pharmacotherapy; Psychiatry; Quality control; Risk Factors