Antibody-Dependent Cellular Cytotoxicity Activity of Effector Cells from HIV-Infected Elite and Viral Controllers

• Published in: AIDS research and human retroviruses Vol. 32; no. 10-11; p. 1079
• Main Authors: Isitman, Gamze, Lisovsky, Irene, Tremblay-McLean, Alexandra, Kovacs, Colin, Harris, Marianne, Routy, Jean-Pierre, Bruneau, Julie, Wainberg, Mark A, Tremblay, Cécile, Bernard, Nicole F
• Format: Journal Article
• Language: English
• Published: United States 01.11.2016
• Subjects: Antibodies; Antibody-Dependent Cell Cytotoxicity; Cohort Studies; Genotype; HIV Infections - immunology; HIV Long-Term Survivors; HLA-B Antigens - genetics; Humans; Killer Cells, Natural - immunology; Longitudinal Studies; Receptors, KIR3DL1 - genetics; NK cells; HIV; slow progressors; HLA; KIR; ADCC

Carriage of alleles encoding certain inhibitory natural killer (NK) cell receptor/HLA ligand KIR3DL1/HLA-B combinations is associated with protection from HIV infection and slow time to AIDS, implicating NK cells in HIV control. NK cells also mediate antibody-dependent cellular cytotoxicity (ADCC)....