Anti-inflammatory effects of coumarins on a murine model of acute lung injury (ALI): a brief systematic review
Acute lung injury (ALI) is one of most critical inflammatory conditions. It is produced by different scenarios, which poses a challenge for its clinical management and treatment. Coumarins, a class of natural and synthetic compounds, identified as important candidates for new drugs due to their anti...
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| Published in | Advances in traditional medicine (Online) Vol. 24; no. 2; pp. 413 - 429 |
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| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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Singapore
Springer Nature Singapore
01.06.2024
융합한의과학연구소 |
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| Abstract | Acute lung injury (ALI) is one of most critical inflammatory conditions. It is produced by different scenarios, which poses a challenge for its clinical management and treatment. Coumarins, a class of natural and synthetic compounds, identified as important candidates for new drugs due to their anti-inflammatory action, could be an alternative for the development of new medicines to manage ALI. In this article, we compile the results of a literature review to conclude whether coumarins are as effective as anti-inflammatory compounds when used in LPS-induced ALI in mice. The outcomes used as parameters to answer this question were: the ability to reduce the influx of inflammatory cells, and edema in inflamed lungs. A total of eight manuscripts were reviewed that unanimously addressed the anti-inflammatory efficacy of coumarin compounds in inhibiting the formation of edema and the influx of leukocytes into the lungs in LPS-induced ALI in mice. Most of the studies also highlighted the role of compounds in decreasing the production of pro-inflammatory cytokines, and these effects were associated with interference in the cell signaling pathways, which were investigated by some of the studies included in this review. The assessment of methodological quality showed that the studies evaluated in this review had moderate to high risk of bias, related to the lack of data on randomization of the animals, and the blinding of the investigators, compromising the reliability of the experimental results of the published works. Leading the results of the manuscripts is possible affirm that coumarins have important anti-inflammatory effects in LPS-induced ALI in mice, and the effect is comparable to the reference anti-inflammatory drug dexamethasone.
Graphical abstract |
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| AbstractList | Acute lung injury (ALI) is one of most critical infammatory conditions. It is produced by diferent scenarios, which poses a challenge for its clinical management and treatment. Coumarins, a class of natural and synthetic compounds, identifed as important candidates for new drugs due to their anti-infammatory action, could be an alternative for the development of new medicines to manage ALI. In this article, we compile the results of a literature review to conclude whether coumarins are as efective as anti-infammatory compounds when used in LPS-induced ALI in mice. The outcomes used as parameters to answer this question were: the ability to reduce the infux of infammatory cells, and edema in infamed lungs. A total of eight manuscripts were reviewed that unanimously addressed the anti-infammatory efcacy of coumarin compounds in inhibiting the formation of edema and the infux of leukocytes into the lungs in LPS-induced ALI in mice. Most of the studies also highlighted the role of compounds in decreasing the production of pro-infammatory cytokines, and these efects were associated with interference in the cell signaling pathways, which were investigated by some of the studies included in this review. The assessment of methodological quality showed that the studies evaluated in this review had moderate to high risk of bias, related to the lack of data on randomization of the animals, and the blinding of the investigators, compromising the reliability of the experimental results of the published works. Leading the results of the manuscripts is possible afrm that coumarins have important anti-infammatory efects in LPS-induced ALI in mice, and the efect is comparable to the reference anti-infammatory drug dexamethasone. KCI Citation Count: 0 Acute lung injury (ALI) is one of most critical inflammatory conditions. It is produced by different scenarios, which poses a challenge for its clinical management and treatment. Coumarins, a class of natural and synthetic compounds, identified as important candidates for new drugs due to their anti-inflammatory action, could be an alternative for the development of new medicines to manage ALI. In this article, we compile the results of a literature review to conclude whether coumarins are as effective as anti-inflammatory compounds when used in LPS-induced ALI in mice. The outcomes used as parameters to answer this question were: the ability to reduce the influx of inflammatory cells, and edema in inflamed lungs. A total of eight manuscripts were reviewed that unanimously addressed the anti-inflammatory efficacy of coumarin compounds in inhibiting the formation of edema and the influx of leukocytes into the lungs in LPS-induced ALI in mice. Most of the studies also highlighted the role of compounds in decreasing the production of pro-inflammatory cytokines, and these effects were associated with interference in the cell signaling pathways, which were investigated by some of the studies included in this review. The assessment of methodological quality showed that the studies evaluated in this review had moderate to high risk of bias, related to the lack of data on randomization of the animals, and the blinding of the investigators, compromising the reliability of the experimental results of the published works. Leading the results of the manuscripts is possible affirm that coumarins have important anti-inflammatory effects in LPS-induced ALI in mice, and the effect is comparable to the reference anti-inflammatory drug dexamethasone. Graphical abstract |
| Author | Lubschinski, Tainá Larissa dos Reis, Gustavo Oliveira Felisberto, Mariano da Silva Buss, Ziliani Dalmarco, Eduardo Monguilhott Mohr, Eduarda Talita Bramorski Matheus, Filipe Carvalho Ribeiro, Thais Elisete Pilatti da Rosa, Júlia Salvan |
| Author_xml | – sequence: 1 givenname: Gustavo Oliveira surname: dos Reis fullname: dos Reis, Gustavo Oliveira organization: Postgraduation Program in Pharmacy, Federal University of Santa Catarina – sequence: 2 givenname: Ziliani surname: da Silva Buss fullname: da Silva Buss, Ziliani organization: Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina – sequence: 3 givenname: Tainá Larissa surname: Lubschinski fullname: Lubschinski, Tainá Larissa organization: Postgraduation Program in Pharmacy, Federal University of Santa Catarina – sequence: 4 givenname: Eduarda Talita Bramorski surname: Mohr fullname: Mohr, Eduarda Talita Bramorski organization: Postgraduation Program in Pharmacy, Federal University of Santa Catarina – sequence: 5 givenname: Mariano surname: Felisberto fullname: Felisberto, Mariano organization: Postgraduation Program in Pharmacy, Federal University of Santa Catarina – sequence: 6 givenname: Thais Elisete Pilatti surname: Ribeiro fullname: Ribeiro, Thais Elisete Pilatti organization: Postgraduation Program in Pharmacy, Federal University of Santa Catarina – sequence: 7 givenname: Júlia Salvan surname: da Rosa fullname: da Rosa, Júlia Salvan organization: Postgraduation Program in Pharmacy, Federal University of Santa Catarina – sequence: 8 givenname: Filipe Carvalho surname: Matheus fullname: Matheus, Filipe Carvalho organization: Department of Pharmaceutical Sciences, Federal University of Santa Catarina – sequence: 9 givenname: Eduardo Monguilhott orcidid: 0000-0002-5220-5396 surname: Dalmarco fullname: Dalmarco, Eduardo Monguilhott email: eduardo.dalmarco@ufsc.br, edalmarco@gmail.com organization: Postgraduation Program in Pharmacy, Federal University of Santa Catarina, Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina |
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| Cites_doi | 10.1016/j.plipres.2009.06.002 10.2174/1389557516666160801094919 10.3390/molecules23020250 10.1016/j.ejmech.2016.07.057 10.1016/j.jep.2021.114924 10.1016/j.ejmech.2020.113034 10.1007/s10753-020-01182-4 10.1007/s00018-020-03656-y 10.1039/C6RA18293C 10.1136/bmj.n71 10.1128/IAI.00095-21 10.3390/ijms20236008 10.1097/PSN.0b013e318256d638 10.1371/journal.pmed.1000097 10.1136/thorax.57.6.540 10.1186/s13643-016-0384-4 10.2174/1389450122666210222091412 10.1016/j.intimp.2014.12.041 10.1007/s10753-015-0127-z 10.1111/prd.12034 10.1371/journal.pone.0098856 10.1038/s41572-019-0069-0 10.1165/rcmb.2009-0047TR 10.1186/1471-2288-14-43 10.1007/978-3-030-68748-9_14 10.1016/j.cpsurg.2020.100777 10.1097/00007890-196911000-00015 10.1165/rcmb.2009-0210ST 10.1016/j.ejphar.2022.174867 10.3109/10715762.2015.1087643 10.1016/j.intimp.2019.05.032 10.3389/fphys.2020.00036 10.1038/nri3399 10.18632/oncotarget.23208 10.1016/j.immuni.2014.10.008 10.1016/j.jclinepi.2014.04.008 10.1016/j.jep.2014.07.033 10.1155/2021/6492346 10.1002/9781119536604 |
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| Snippet | Acute lung injury (ALI) is one of most critical inflammatory conditions. It is produced by different scenarios, which poses a challenge for its clinical... Acute lung injury (ALI) is one of most critical infammatory conditions. It is produced by diferent scenarios, which poses a challenge for its clinical... |
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| Title | Anti-inflammatory effects of coumarins on a murine model of acute lung injury (ALI): a brief systematic review |
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