Peripheral chemoreceptor responsiveness and hypoxic pulmonary vasoconstriction in humans

• Published in: High altitude medicine & biology Vol. 15; no. 1; p. 15
• Main Authors: Albert, Tyler J, Swenson, Erik R
• Format: Journal Article
• Language: English
• Published: United States 01.04.2014
• Subjects: Adult; Blood Pressure; Carbon Dioxide; Chemoreceptor Cells - physiology; Female; Heart Rate; Humans; Hypoxia - physiopathology; Lung - blood supply; Male; Oxygen - blood; Partial Pressure; Pulmonary Artery - diagnostic imaging; Pulmonary Artery - physiology; Pulmonary Ventilation; Respiratory Rate; Tidal Volume; Ultrasonography; Vasoconstriction - physiology

Studies in animals have shown that interruption of carotid body afferent hypoxic signaling or efferent CNS activity to the lung enhances hypoxic pulmonary vasoconstriction (HPV). Whether a similar influence of the CNS on HPV strength is present in humans has never been studied, owing to the invasive...