Septin genomics: a road less travelled

The human septins are part of a gene family, that is a group of genes with similar sequences and usually but not invariably share similar functions that are descended from a common ancestor. Here we review our current knowledge of the human septin gene family and highlight areas of uncertainty. Curr...

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Published inBiological chemistry Vol. 392; no. 8-9; pp. 763 - 767
Main Authors Russell, S.E. Hilary, Hall, Peter A.
Format Journal Article
LanguageEnglish
Published Germany Walter de Gruyter 01.08.2011
Subjects
Cell Cycle Proteins - classification
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
gene family
Genomics - methods
Humans
nonsense mediated decay
Nonsense Mediated mRNA Decay - genetics
Nonsense Mediated mRNA Decay - physiology
Protein Isoforms - classification
Protein Isoforms - genetics
Protein Isoforms - metabolism
pseudogene
regulation
septin
Septins - classification
Septins - genetics
Septins - metabolism
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Abstract The human septins are part of a gene family, that is a group of genes with similar sequences and usually but not invariably share similar functions that are descended from a common ancestor. Here we review our current knowledge of the human septin gene family and highlight areas of uncertainty. Currently 13 human septin genes are known (SEPT1 to SEPT12 and SEPT14). What was known as SEPT13 is now defined as one of many SEPT7 related pseudogenes. The family is characterized by complex genomics and extensive (but not universal) splicing, giving rise to a plethora of septin isoforms. For only a few members of the family do we have a comprehensive insight into these transcripts and isoforms. Given the formation of countless septin homotypic and heterotypic interactions our understanding of the biology and pathobiology of the septin family will require a detailed understanding of the genomics, transcriptomics and regulation of all members of this diverse and complex family.
AbstractList The human septins are part of a gene family, that is a group of genes with similar sequences and usually but not invariably share similar functions that are descended from a common ancestor. Here we review our current knowledge of the human septin gene family and highlight areas of uncertainty. Currently 13 human septin genes are known (SEPT1 to SEPT12 and SEPT14). What was known as SEPT13 is now defined as one of many SEPT7 related pseudogenes. The family is characterized by complex genomics and extensive (but not universal) splicing, giving rise to a plethora of septin isoforms. For only a few members of the family do we have a comprehensive insight into these transcripts and isoforms. Given the formation of countless septin homotypic and heterotypic interactions our understanding of the biology and pathobiology of the septin family will require a detailed understanding of the genomics, transcriptomics and regulation of all members of this diverse and complex family.
The human septins are part of a gene family, that is a group of genes with similar sequences and usually but not invariably share similar functions that are descended from a common ancestor. Here we review our current knowledge of the human septin gene family and highlight areas of uncertainty. Currently 13 human septin genes are known ( SEPT1 to SEPT1 2 and SEPT14 ). What was known as SEPT13 is now defined as one of many SEPT7 related pseudogenes. The family is characterized by complex genomics and extensive (but not universal) splicing, giving rise to a plethora of septin isoforms. For only a few members of the family do we have a comprehensive insight into these transcripts and isoforms. Given the formation of countless septin homotypic and heterotypic interactions our understanding of the biology and pathobiology of the septin family will require a detailed understanding of the genomics, transcriptomics and regulation of all members of this diverse and complex family.
Author Russell, S.E. Hilary
Hall, Peter A.
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Snippet The human septins are part of a gene family, that is a group of genes with similar sequences and usually but not invariably share similar functions that are...
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SubjectTerms Cell Cycle Proteins - classification
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
gene family
Genomics - methods
Humans
nonsense mediated decay
Nonsense Mediated mRNA Decay - genetics
Nonsense Mediated mRNA Decay - physiology
Protein Isoforms - classification
Protein Isoforms - genetics
Protein Isoforms - metabolism
pseudogene
regulation
septin
Septins - classification
Septins - genetics
Septins - metabolism
Title Septin genomics: a road less travelled
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