Cytofluorometric analysis of phenotypes of human bone marrow and umbilical fibroblast-like cells

Comparative analysis of the expression of some surface markers of human bone marrow mesenchymal stem cells, umbilical fibroblast-like cells, and skin fibroblasts was carried out by the flow cytofluorometry method. Mesenchymal stem cells and umbilical fibroblast-like cells were similar by the levels...

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Bibliographic Details
Published inBulletin of experimental biology and medicine Vol. 142; no. 4; pp. 521 - 526
Main Authors Lupatov, A Yu, Karalkin, P A, Suzdal'tseva, Yu G, Burunova, V V, Yarygin, V N, Yarygin, K N
Format Journal Article
LanguageEnglish
Russian
Published United States Springer Nature B.V 01.10.2006
Subjects
Antigens, CD - analysis
Bone Marrow Cells - cytology
Bone Marrow Cells - immunology
Fetal Blood - cytology
Fibroblasts - cytology
Fibroblasts - immunology
Flow Cytometry - methods
HLA Antigens - analysis
Humans
Immunohistochemistry
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - immunology
Phenotype
Skin - cytology
Skin - immunology
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Summary:Comparative analysis of the expression of some surface markers of human bone marrow mesenchymal stem cells, umbilical fibroblast-like cells, and skin fibroblasts was carried out by the flow cytofluorometry method. Mesenchymal stem cells and umbilical fibroblast-like cells were similar by the levels of expression of the main histocompatibility complex antigens, adhesion molecules, and some growth factor receptors. The profile of skin fibroblast surface antigens was characterized by higher expression of the markers typical of differentiated cells. The results prove the possibility of using umbilical fibroblast-like cells as an alternative source of mesenchymal stem cells for cell replacement therapy.
Bibliography:ObjectType-Article-1
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ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-006-0407-6