Age-Related Features of the Response of Cancer Stem Cells and T Cells in Experimental Lung Cancer

• Published in: Bulletin of experimental biology and medicine Vol. 176; no. 4; pp. 486 - 490
• Main Authors: Pershina, O. V., Ermakova, N. N., Pakhomova, A. V., Pan, E. S., Sandrikina, L. A., Zhukova, M. A., Kogai, L. V., Dygai, A. M., Skurikhin, E. G.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.02.2024; Springer Nature B.V
• Subjects: Age; Animals; Biomedical and Life Sciences; Biomedicine; Blood; Carcinoma, Lewis Lung - pathology; CD4 antigen; CD8 antigen; CD8-Positive T-Lymphocytes - metabolism; Cell Biology; Cytometry; Internal Medicine; Laboratory animals; Laboratory Medicine; Lung cancer; Lung carcinoma; Lung Neoplasms - pathology; Lymphocytes; Lymphocytes T; Mice; Mice, Inbred C57BL; Neoplastic Stem Cells - metabolism; Older people; Oncology; Pathology; Pharmacology; Regenerative medicine; Stem cells; Tumor cells; Tumors; lung cancer; Lewis lung carcinoma; age features; cancer stem cells; T cells
• ISSN: 0007-4888; 1573-8221; 1573-8221
• DOI: 10.1007/s10517-024-06052-9

The responses of tumor stem cells and various populations of CD4 and CD8 T cells of young and aged C57BL/6 mice were studied in a lung cancer model. Using Lewis lung carcinoma cell line, an orthotopic model of lung cancer was modeled. Cancer stem cells, circulating tumor cells, and various populations of CD4 and CD8 T cells in the blood and lung tissue were studied by cytometry. We revealed age-related differences in the content of various populations of CD4 and CD8 T cells in the blood and lungs of intact young and aged mice. Age-related features of the reaction of various populations of cancer stem cells and CD4 and CD8 T cells in the blood and lungs of animals in the Lewis lung carcinoma were shown.