Sex differences in mitochondrial free-carnitine levels in subjects at-risk and with Alzheimer’s disease in two independent study cohorts

• Published in: Molecular psychiatry Vol. 30; no. 6; pp. 2573 - 2583
• Main Authors: Bigio, Benedetta, Lima-Filho, Ricardo A. S., Barnhill, Olivia, Sudo, Felipe K., Drummond, Claudia, Assunção, Naima, Vanderborght, Bart, Beasley, James, Young, Sarah, Korman, Aryeh, Jones, Drew R., Sultzer, David L., Ferreira, Sergio T., Mattos, Paulo, Head, Elizabeth, Tovar-Moll, Fernanda, De Felice, Fernanda G., Lourenco, Mychael V., Nasca, Carla
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2025; Nature Publishing Group
• Subjects: 631/337; 692/699/476; 82/58; Acetyl-L-carnitine; Acetylcarnitine - blood; Acetylcarnitine - metabolism; Aged; Aged, 80 and over; Alzheimer Disease - blood; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Behavioral Sciences; Biological Psychology; Biomarkers - blood; Carnitine; Carnitine - blood; Carnitine - metabolism; Cerebrospinal fluid; Cognition - physiology; Cognitive ability; Cognitive Dysfunction - blood; Cognitive Dysfunction - metabolism; Cohort Studies; Epigenetics; Female; Gene expression; Humans; Independent study; Male; Medicine; Medicine & Public Health; Metabolism; Middle Aged; Mitochondria; Mitochondria - metabolism; Molecular modelling; Neurodegenerative diseases; Neurosciences; Pharmacotherapy; Psychiatry; Sex Characteristics; Sex differences; Sex Factors; Tau protein; tau Proteins - cerebrospinal fluid; Women; β-Amyloid
• ISSN: 1359-4184; 1476-5578; 1476-5578
• DOI: 10.1038/s41380-024-02862-5

A major challenge in the development of more effective therapeutic strategies for Alzheimer’s disease (AD) is the identification of molecular mechanisms linked to specific pathophysiological features of the disease. Importantly AD has a two-fold higher incidence in women than men and a protracted pr...