Silencing suppressor of cytokine signaling 3 induces apoptosis and activates the p-STAT3/NF-κB pathway in hypoxic cultivated H9c2 cells

• Published in: Journal of physiology and biochemistry Vol. 80; no. 1; pp. 127 - 136
• Main Authors: Gu, Qiang, Xiao, Ying-Bin, Wang, Yong
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.02.2024; Springer Nature B.V
• Subjects: Animal Physiology; Apoptosis; Bcl-2 protein; Biomedical and Life Sciences; Biomedicine; Cardiomyocytes; Caspase-3; Cell signaling; Cell viability; Cytokines; Cytokines - metabolism; Gene expression; Human Physiology; Humans; Hypoxia; Hypoxia - metabolism; Injury prevention; Molecular modelling; Myocytes, Cardiac - metabolism; NF-kappa B - metabolism; NF-κB protein; Original Article; Signal Transduction; SOCS-3 protein; Stat3 protein; STAT3 Transcription Factor - metabolism; Myocardial adaptation; SOCS3; NF-κB; Hypoxia; STAT3; Apoptosis

Suppressor of cytokine signaling 3 (SOCS3) plays a significant role in the process of myocardial adaptation to chronic hypoxia. SOCS3 finely regulates cell signaling cross-talk that occurs between NF-κB and STAT3 during the compensatory protective response. However, the role and mechanism of SOCS3 i...