Identification of extracellular matrix proteins in plasma as a potential biomarker for intervertebral disc degeneration

• Published in: European spine journal Vol. 33; no. 11; pp. 4062 - 4075
• Main Authors: Nayagam, Sharon Miracle, Ramachandran, Karthik, Selvaraj, Ganesh, Sunmathi, R., Easwaran, Murugesh, Palraj, Narmatha Devi, Anand K. S., Sri Vijay, Muthurajan, Raveendran, Tangavel, Chitraa, Rajasekaran, S.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.11.2024; Springer Nature B.V
• Subjects: Adult; Aggrecan; Aggrecans - blood; Aggrecans - metabolism; Biomarkers; Biomarkers - blood; Calcium-Binding Proteins - blood; Collagen; Degeneration; Degenerative disc disease; Extracellular matrix; Extracellular Matrix Proteins - blood; Female; Humans; Immunoglobulin G; Intervertebral Disc Degeneration - blood; Intervertebral discs; Male; Medicine; Medicine & Public Health; Middle Aged; Neurosurgery; Nucleus pulposus; Original Article; Plasma; Proteins; Proteolysis; Proteomics; Proteomics - methods; Statistical analysis; Surgical Orthopedics; Collagen type 2a1; Fibulin 1; Disc degeneration; Extracellular matrix proteins; Plasma biomarker; Proteomics; Aggrecan

Purpose Recently, there has been significant focus on extracellular matrix proteolysis due to its importance in the pathological progression of intervertebral disc degeneration (IVDD). The present study investigates the circulating levels of extracellular matrix proteins in the plasma of IVDD and de...